COMT (NM_007310) Human Mass Spec Standard

CAT#: PH304127

COMT MS Standard C13 and N15-labeled recombinant protein (NP_009294)



  View other "COMT" proteins (5)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of catechol-O-methyltransferase (COMT), transcript variant 1
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Specifications

Product Data
Description COMT MS Standard C13 and N15-labeled recombinant protein (NP_009294)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC204127
Predicted MW 24.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_009294
RefSeq Size 2035
RefSeq ORF 663
Synonyms HEL-S-98n
Locus ID 1312
Cytogenetics 22q11.21
Summary Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Metabolic pathways, Tyrosine metabolism
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