Estrogen Receptor beta (ESR2) Human Gene Knockout Kit (CRISPR)

CAT#: KN212665RB

ESR2 - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

  See Other Versions

CNY 12,260.00


货期*
6周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


ESR2 mouse monoclonal antibody,clone OTI2E12
    • 100 ul

CNY 1,999.00
CNY 2,700.00


ESR2 (Myc-DDK-tagged)-Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a
    • 10 ug

CNY 5,920.00

Specifications

Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA RFP-BSD
Symbol Estrogen Receptor beta
Locus ID 2100
Kit Components

KN212665G1, Estrogen Receptor beta gRNA vector 1 in pCas-Guide CRISPR vector

KN212665G2, Estrogen Receptor beta gRNA vector 2 in pCas-Guide CRISPR vector

KN212665RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001040275, NM_001040276, NM_001214902, NM_001214903, NM_001271876, NM_001271877, NM_001291712, NM_001291723, NM_001437, NR_073496, NR_073497, NR_073505
Synonyms ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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