NFKB1 Human Gene Knockout Kit (CRISPR)
CAT#: KN208384LP
NFKB1 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 7,096.00
CNY 1,999.00
CNY 3,490.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | NFKB1 |
Locus ID | 4790 |
Kit Components |
KN208384G1, NFKB1 gRNA vector 1 in pCas-Guide CRISPR vector KN208384G2, NFKB1 gRNA vector 2 in pCas-Guide CRISPR vector KN208384LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001165412, NM_001319226, NM_003998 |
Synonyms | CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kB1; NFkappaB; NFKB-p50; NFKB-p105; p50; p105 |
Summary | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN208384 | NFKB1 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN208384BN | NFKB1 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN208384RB | NFKB1 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN408384 | NFKB1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
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GA103192 | NFKB1 CRISPRa kit - CRISPR gene activation of human nuclear factor kappa B subunit 1 |
CNY 12,255.00 |