Human beta Catenin (CTNNB1) activation kit by CRISPRa

CAT#: GA101060

CTNNB1 CRISPRa kit - CRISPR gene activation of human catenin beta 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
CTNNB1 mouse monoclonal antibody, clone OTI12H7 (formerly 12H7)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


CTNNB1 (Myc-DDK-tagged)-Human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
    • 10 ug

CNY 8,576.00


CTNNB1 mouse monoclonal antibody, clone OTI2F10 (formerly 2F10)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol CTNNB1
Locus ID 1499
Kit Components

GA101060G1, beta Catenin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101060G2, beta Catenin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101060G3, beta Catenin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001098209, NM_001098210, NM_001904, NM_001330729
Synonyms armadillo; CTNNB; MRD19
Summary The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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