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CD56 (NCAM1) (NM_001076682) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC213417L3V
- LentiORF®
-
Lenti ORF particles, NCAM1 (Myc-DDK-tagged)-Human neural cell adhesion molecule 1 (NCAM1), transcript variant 3, 200ul, >10^7 TU/mL
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CNY 14,250.00
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CNY 2,700.00
CNY 2,950.00
Specifications
| Product Data | |
| Product Name | CD56 (NCAM1) (NM_001076682) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CD56; MSK39; NCAM |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001076682 |
| ORF Size | 2283 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC213417).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001076682.3 |
| RefSeq Size | 4944 bp |
| RefSeq ORF | 2286 bp |
| Locus ID | 4684 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Prion diseases |
| MW | 83.8 kDa |
| Gene Summary | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020] |
Documents
| Product Manuals |
| FAQs |
| SDS |
