CACNA1E (NM_001205294) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	BII; CACH6; CACNL1A6; Cav2.3; DEE69; EIEE69; gm139
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331650 representing NM_001205294. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCTCGCTTCGGGGAGGCGGTGGTCGCCAGGCCAGGGTCCGGCGATGGAGACTCGGACCAGAGCAGG AACCGGCAAGGAACCCCCGTGCCGGCCTCGGGGCAGGCGGCCGCCTACAAGCAGACGAAAGCACAGAGG GCGCGGACTATGGCTTTGTACAACCCCATTCCCGTCCGGCAGAACTGTTTCACCGTCAACAGATCCCTG TTCATCTTCGGAGAAGATAACATTGTCAGGAAATATGCCAAGAAGCTCATCGATTGGCCGCCATTTGAG TACATGATCCTGGCCACCATCATTGCCAACTGCATCGTCCTGGCCCTGGAGCAGCATCTTCCTGAGGAT GACAAGACCCCCATGTCCCGAAGACTGGAGAAGACAGAACCTTATTTCATTGGGATCTTTTGCTTTGAA GCTGGGATCAAAATTGTGGCCCTGGGGTTCATCTTCCATAAGGGCTCTTACCTCCGCAATGGCTGGAAT GTCATGGACTTCATCGTGGTCCTCAGTGGCATCCTGGCCACTGCAGGAACCCACTTCAATACTCACGTG GACCTGAGGACCCTCCGGGCTGTGCGTGTCCTGCGGCCTTTGAAGCTCGTGTCAGGGATACCTAGCCTG CAGATTGTGTTGAAGTCCATCATGAAGGCCATGGTACCTCTTCTGCAGATTGGCCTTCTGCTCTTCTTT GCCATCCTGATGTTTGCTATCATTGGTTTGGAGTTCTACAGTGGCAAGTTACATCGAGCATGCTTCATG AACAATTCAGGTATTCTAGAAGGATTTGACCCCCCTCACCCATGTGGTGTGCAGGGCTGCCCAGCTGGT TATGAATGCAAGGACTGGATCGGCCCCAATGATGGGATCACCCAGTTTGATAACATCCTTTTTGCTGTG CTGACTGTCTTCCAGTGCATCACCATGGAAGGGTGGACCACTGTGCTGTACAATACCAATGATGCCTTA GGAGCCACCTGGAATTGGCTGTACTTCATCCCCCTCATCATCATTGGATCCTTCTTTGTTCTCAACCTA GTCCTGGGAGTGCTTTCCGGGGAATTTGCCAAAGAGAGAGAGAGAGTGGAGAACCGAAGGGCTTTCATG AAGCTGCGGCGCCAGCAGCAGATTGAGCGTGAGCTGAATGGCTACCGTGCCTGGATAGACAAAGCAGAG GAAGTCATGCTCGCTGAAGAAAATAAAAATGCTGGAACATCCGCCTTAGAAGTGCTTCGAAGGGCAACC ATCAAGAGGAGCCGGACAGAGGCCATGACTCGAGACTCCAGTGATGAGCACTGTGTTGATATCTCCTCT GTGGGCACACCTCTGGCCCGAGCCAGTATCAAAAGTGCAAAGGTAGACGGGGTCTCTTATTTCCGGCAC AAGGAAAGGCTTCTGCGCATCTCCATTCGCCACATGGTTAAATCCCAGGTGTTTTACTGGATTGTGCTG AGCCTTGTGGCACTCAACACTGCCTGTGTGGCCATTGTCCATCACAACCAGCCCCAGTGGCTCACCCAC CTCCTCTACTATGCAGAATTTCTGTTTCTGGGACTCTTCCTCTTGGAGATGTCCCTGAAGATGTATGGC ATGGGGCCTCGCCTTTATTTTCACTCTTCATTCAACTGCTTTGATTTTGGGGTCACAGTGGGCAGTATC TTTGAAGTGGTCTGGGCAATCTTCAGACCTGGTACGTCTTTTGGAATCAGTGTCTTGCGAGCCCTCCGG CTTCTAAGAATATTTAAAATAACCAAGTATTGGGCTTCCCTACGGAATTTGGTGGTCTCCTTGATGAGC TCAATGAAGTCTATCATCAGTTTGCTTTTCCTCCTCTTCCTCTTCATCGTTGTCTTTGCTCTCCTAGGA ATGCAGTTATTTGGAGGCAGGTTTAACTTTAATGATGGGACTCCTTCGGCAAATTTTGATACCTTCCCT GCAGCCATCATGACTGTGTTCCAGATCCTGACGGGTGAGGACTGGAATGAGGTGATGTACAATGGGATC CGCTCCCAGGGTGGGGTCAGCTCAGGCATGTGGTCTGCCATCTACTTCATTGTGCTCACCTTGTTTGGC AACTACACGCTACTGAATGTGTTCTTGGCTATCGCTGTGGATAATCTCGCCAACGCCCAGGAACTGACC AAGGATGAACAGGAGGAAGAAGAGGCCTTCAACCAGAAACATGCACTGCAGAAGGCCAAGGAGGTCAGC CCGATGTCTGCACCCAACATGCCTTCGATCGAGAGGGAGCGGAGGCGCCGGCACCACATGTCCGTGTGG GAGCAGCGTACCAGCCAGCTGAGGAAGCACATGCAGATGTCCAGCCAGGAGGCCCTCAACAGAGAGGAG GCGCCGACCATGAACCCGCTCAACCCCCTCAACCCGCTCAGCTCCCTCAACCCGCTCAATGCCCACCCC AGCCTTTATCGGCGACCCAGGGCCATTGAGGGCCTGGCCCTGGGCCTGGCCCTGGAGAAGTTCGAGGAG GAGCGCATCAGCCGTGGGGGGTCCCTCAAGGGGGATGGAGGGGACCGATCCAGTGCCCTGGACAACCAG AGGACCCCTTTGTCCCTGGGCCAGCGGGAGCCACCATGGCTGGCCAGGCCCTGTCATGGAAACTGTGAC CCGACTCAGCAGGAGGCAGGGGGAGGAGAGGCTGTGGTGACCTTTGAGGACCGGGCCAGGCACAGGCAG AGCCAACGGCGCAGCCGGCATCGCCGCGTCAGGACAGAAGGCAAGGAGTCCTCTTCAGCCTCCCGGAGC AGGTCTGCCAGCCAGGAACGCAGTCTGGATGAAGCCATGCCCACTGAAGGGGAGAAGGACCATGAGCTC AGGGGCAACCATGGTGCCAAGGAGCCAACGATCCAAGAAGAGAGAGCCCAGGATTTAAGGAGGACCAAC AGTCTGATGGTGTCCAGAGGCTCCGGGCTGGCAGGAGGCCTTGATGAGGCTGACACCCCCCTAGTCCTG CCCCATCCTGAGCTGGAAGTGGGGAAGCACGTGGTGCTGACGGAGCAGGAGCCAGAAGGCAGCAGTGAG CAGGCCCTGCTGGGGAATGTGCAGCTAGACATGGGCCGGGTCATCAGCCAGAGCGAGCCTGACCTCTCC TGCATCACGGCCAACACGGACAAGGCCACCACCGAGAGCACCAGCGTCACCGTCGCCATCCCCGACGTG GACCCCTTGGTGGACTCAACCGTGGTGCACATTAGCAACAAGACGGATGGGGAAGCCAGTCCCTTGAAG GAGGCAGAGATCAGAGAGGATGAGGAGGAGGTGGAGAAGAAGAAGCAGAAGAAGGAGAAGCGTGAGACA GGCAAAGCCATGGTGCCCCACAGCTCAATGTTCATCTTCAGCACCACCAACCCGATCCGGAGGGCCTGC CACTACATCGTGAACCTGCGCTACTTTGAGATGTGCATCCTCCTGGTGATTGCAGCCAGCAGCATCGCC CTGGCGGCAGAGGACCCCGTCCTGACCAACTCGGAGCGCAACAAAGTCCTGAGGTATTTTGACTATGTG TTCACGGGCGTGTTCACCTTTGAGATGGTTATAAAGATGATAGACCAAGGCTTGATCCTGCAGGATGGG TCCTACTTCCGAGACTTGTGGAACATCCTGGACTTTGTGGTGGTCGTTGGCGCATTGGTGGCCTTTGCT CTGGCGAACGCTTTGGGAACCAACAAAGGACGGGACATCAAGACCATCAAGTCTCTGCGGGTGCTCCGA GTTCTAAGGCCACTGAAAACCATCAAGCGCTTGCCCAAGCTCAAGGCCGTCTTCGACTGCGTAGTGACC TCCTTGAAGAATGTCTTCAACATACTCATTGTGTACAAGCTCTTCATGTTCATCTTTGCTGTCATCGCA GTTCAGCTCTTCAAGGGAAAGTTCTTTTATTGCACGGACAGTTCCAAGGACACAGAGAAGGAGTGCATA GGCAACTATGTAGATCATGAGAAAAACAAGATGGAGGTGAAGGGCCGGGAATGGAAGCGCCATGAATTC CACTACGACAACATTATCTGGGCCCTGCTGACCCTCTTCACCGTCTCCACAGGGGAAGGATGGCCTCAA GTTCTGCAGCACTCTGTAGATGTGACAGAGGAAGACCGAGGCCCAAGCCGCAGCAACCGCATGGAGATG TCTATCTTTTATGTAGTCTACTTTGTGGTCTTCCCCTTCTTCTTTGTCAATATCTTTGTGGCTCTCATC ATCATCACCTTCCAGGAGCAAGGGGATAAGATGATGGAGGAGTGCAGCCTGGAGAAGAATGAGAGGGCG TGCATCGACTTCGCCATCAGCGCCAAACCTCTCACCCGCTACATGCCGCAGAACAGACACACCTTCCAG TACCGCGTGTGGCACTTTGTGGTGTCTCCGTCCTTTGAGTACACCATTATGGCCATGATCGCCTTGAAT ACTGTTGTGCTGATGATGAAGTATTATTCTGCTCCCTGTACCTATGAGCTGGCCCTGAAGTACCTGAAT ATCGCCTTCACCATGGTGTTTTCCCTGGAATGTGTCCTGAAGGTCATCGCTTTTGGCTTTTTGAACTAT TTCCGAGACACCTGGAATATCTTTGACTTCATCACCGTGATTGGCAGTATCACAGAAATTATCCTGACA GACAGCAAGCTGGTGAACACCAGTGGCTTCAATATGAGCTTTCTGAAGCTCTTCCGAGCTGCCCGCCTC ATAAAGCTCCTGCGTCAGGGCTATACCATACGCATTTTGCTGTGGACCTTTGTGCAGTCCTTTAAGGCC CTCCCTTATGTCTGCCTTTTAATTGCCATGCTTTTCTTCATTTATGCCATCATTGGGATGCAGGTATTT GGAAACATAAAATTAGACGAGGAGAGTCACATCAACCGGCACAACAACTTCCGGAGTTTCTTTGGGTCC CTAATGCTACTCTTCAGGAGTGCCACAGGTGAGGCCTGGCAGGAGATTATGCTGTCATGCCTTGGGGAG AAGGGCTGTGAGCCTGACACCACCGCACCATCAGGGCAGAACGAGAACGAACGCTGCGGCACCGATCTG GCCTACGTGTACTTTGTCTCCTTCATCTTCTTCTGCTCCTTCTTGATGCTCAACCTGTTTGTGGCCGTC ATCATGGACAACTTTGAGTACCTGACTCGGGACTCCTCCATCCTGGGGCCTCACCACTTGGACGAGTTT GTCCGCGTCTGGGCAGAATATGACCGAGCAGCATGTGGCCGCATCCATTACACTGAGATGTATGAAATG CTGACTCTCATGTCACCTCCGCTAGGCCTCGGCAAGAGATGTCCCTCCAAAGTGGCATATAAGAGGTTG GTCCTGATGAACATGCCAGTAGCTGAGGACATGACGGTCCACTTCACCTCCACACTTATGGCTCTGATC CGGACAGCTCTGGACATTAAAATTGCCAAAGGTGGTGCAGACAGGCAGCAGCTAGACTCAGAGCTACAA AAGGAGACCCTAGCCATCTGGCCTCACCTATCCCAGAAGATGCTGGATCTGCTTGTGCCCATGCCCAAA GCCTCTGACCTGACTGTGGGCAAAATCTATGCAGCAATGATGATCATGGACTACTATAAGCAGAGTAAG GTGAAGAAGCAGAGGCAGCAGCTGGAGGAACAGAAAAATGCCCCCATGTTCCAGCGCATGGAGCCTTCA TCTCTGCCTCAGGAGATCATTGCTAATGCCAAAGCCCTGCCTTACCTCCAGCAGGACCCCGTTTCAGGC CTGAGTGGCCGGAGTGGATACCCTTCGATGAGTCCACTCTCTCCCCAGGATATATTCCAGTTGGCTTGT ATGGACCCCGCCGATGACGGACAGTTCCAAGAACGGCAGTCTCTGGTGGTGACAGACCCTAGCTCCATG AGACGTTCATTTTCCACTATTCGGGATAAGCGTTCAAATTCCTCGTGGTTGGAGGAATTCTCCATGGAG CGAAGCAGTGAAAATACCTACAAGTCCCGTCGCCGGAGTTACCACTCCTCCTTGCGGCTGTCAGCCCAC CGCCTGAACTCTGATTCAGGCCACAAGTCTGACACTCACCGCTCAGGGGGCAGGGAGCGGGGACGATCA AAAGAGCGAAAGCATCTTCTCTCTCCTGATGTCTCCCGCTGCAATTCAGAAGAGCGAGGGACCCAGGCT GACTGGGAGTCCCCAGAGCGCCGTCAATCCAGGTCACCCAGTGAGGGCAGGTCACAGACGCCCAACAGA CAGGGCACAGGTTCCCTAAGTGAGAGCTCCATCCCCTCTGTCTCTGACACCAGCACCCCAAGAAGAAGT CGTCGGCAGCTCCCACCCGTCCCGCCAAAGCCCCGGCCCCTCCTTTCCTACAGCTCCCTGATTCGACAC GCGGGCAGCATCTCTCCACCTGCTGATGGAAGCGAGGAGGGCTCCCCGCTGACCTCCCAAGCTCTGGAG AGCAACAATGCTTGCCTGACCGAGTCTTCCAACTCTCCGCACCCCCAGCAGAGCCAACATGCCTCCCCA CAGCGCTACATCTCCGAGCCCTACTTGGCCCTGCACGAAGACTCCCACGCCTCAGACTGTGGTGAGGAG GAGACGCTCACTTTCGAAGCAGCCGTGGCTACTAGCCTGGGCCGTTCCAACACCATCGGCTCAGCCCCA CCCCTGCGGCATAGCTGGCAGATGCCCAACGGGCACTATCGGCGGCGGAGGCGCGGGGGGCCTGGGCCA GGCATGATGTGTGGGGCTGTCAACAACCTGCTAAGTGACACGGAAGAAGATGACAAATGCTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001205294
Insert Size	6756 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001205294.1
RefSeq Size	14915 bp
RefSeq ORF	6756 bp
Locus ID	777
UniProt ID	Q15878
Protein Families	Druggable Genome, Ion Channels: Calcium, Transmembrane
Protein Pathways	Calcium signaling pathway, MAPK signaling pathway, Type II diabetes mellitus
MW	254.6 kDa
Gene Summary	Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] Transcript Variant: This variant (2) is missing two non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (2, also known as alpha-1E-1) missing two internal protein segments compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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