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NSD1 (NM_172349) Human Untagged Clone
CAT＃: SC306757
NSD1 (untagged)-Human nuclear receptor binding SET domain protein 1 (NSD1), transcript variant 1
CNY 24,040.00
货期*
现货
规格
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经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARA267; KMT3B; SOTOS; SOTOS1; STO |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_172349 edited
ATGCCCCTGAAGACAAGGACAGCCCTTTCGGATGATCCAGATTCCAGTACCAGTACATTA GGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTTCACAGGAATTGCCATTT TGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCA AAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTGATCCGTTGATTAACACA CATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGTACTACGTGGAGGCTTTT GGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCGTCATGTTTGAAGGCAGA CATCAATTCGAAGAGCTACCTGTCCTTAGGAGAAGAGGGAAACAGAAAGAAAAAGGATAT AGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCAGTGTTGGACTTGCAGAA CAGTATGATGTTCCCAAGGGGTCAAAGAACCGAAAATGTATTCCTGGTTCAATCAAGTTG GACAGTGAAGAAGATATGCCATTTGAAGACTGCACAAATGATCCTGAGTCAGAACATGAC CTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTGAACATTCTGCAGATGAG AAGGAAAAGCCTTGCGCTAAATCTCGAGCCAGAAAGAGCTCTGATAATCCAAAAAGGACT AGTGTGAAAAAGGGCCACATACAATTTGAAGCACATAAAGATGAACGGAGGGGAAAGATT CCAGAGAACCTTGGCCTAAACTTTATCTCTGGGGATATATCTGATACGCAGGCCTCTAAT GAACTTTCCAGGATAGCAAATAGCCTCACAGGGTCCAACACTGCCCCAGGAAGTTTTCTG TTTTCTTCCTGTGGAAAAAACACTGCAAAGAAAGAATTTGAGACTTCAAATGGTGACTCT TTATTGGGCTTGCCTGAGGGTGCTTTGATCTCAAAGTGTTCTCGAGAGAAGAATAAACCC CAACGAAGCCTGGTGTGTGGTTCAAAAGTGAAGCTCTGCTATATTGGAGCAGGTGATGAG GAAAAGCGAAGTGATTCCATTAGTATCTGTACCACTTCTGATGATGGAAGCAGTGACCTG GATCCCATAGAACACAGCTCAGAGTCTGATAACAGTGTCCTTGAAATTCCAGATGCTTTC GATAGAACAGAGAACATGTTATCTATGCAGAAAAATGAAAAGATAAAGTATTCTAGGTTT GCTGCCACAAACACTAGGGTAAAAGCAAAACAGAAGCCTCTCATTAGTAACTCACATACA GACCACTTAATGGGTTGTACTAAGAGTGCAGAGCCTGGAACCGAGACGTCTCAGGTTAAT CTCTCTGATCTGAAGGCATCTACTCTTGTTCACAAACCCCAGTCAGATTTTACAAATGAT GCTCTCTCTCCAAAATTCAACCTGTCATCAAGCATATCCAGTGAGAACTCGTTAATAAAG GGTGGGGCAGCAAATCAAGCTCTATTACATTCGAAAAGCAAACAGCCCAAGTTCCGAAGT ATAAAGTGCAAACACAAAGAAAATCCAGTTATGGCAGAACCCCCAGTTATAAATGAGGAG TGCAGTTTGAAATGCTGCTCTTCTGATACCAAAGGCTCTCCTTTGGCCAGCATTTCTAAA AGTGGGAAAGTGGATGGTCTAAAACTACTGAACAATATGCATGAGAAAACCAGGGATTCA AGTGACATAGAAACAGCAGTGGTGAAACATGTTTTATCCGAGTTGAAGGAACTCTCTTAC AGATCCTTAGGTGAGGATGTCAGTGACTCTGGAACATCAAAGCCATCAAAACCATTACTT TTCTCTTCTGCTTCTAGTCAGAATCACATACCTATTGAACCAGACTACAAATTCAGTACA TTGCTAATGATGTTGAAAGATATGCATGATAGTAAGACGAAGGAGCAGCGGTTGATGACT GCTCAAAACCTGGTCTCTTACCGGAGTCCTGGTCGTGGGGACTGTTCTACTAATAGTCCT GTAGGAGTCTCTAAGGTTTTGGTTTCAGGAGGCTCCACACACAATTCAGAGAAAAAGGGA GATGGCACTCAGAACTCCGCCAATCCTAGCCCTAGTGGGGGTGACTCTGCATTATCTGGC GAGTTGTCTGCTTCCCTACCTGGCTTACTGTCCGACAAGAGAGACCTCCCTGCTTCTGGT AAAAGTCGTTCAGACTGTGTTACTAGGCGCAACTGTGGACGATCAAAGCCTTCATCCAAA TTGCGAGATGCTTTTTCAGCCCAAATGGTAAAGAACACAGTGAACCGTAAAGCCTTAAAG ACCGAGCGCAAAAGAAAACTGAATCAGCTTCCAAGTGTGACTCTTGATGCTGTACTGCAG GGAGACCGAGAACGTGGAGGTTCATTGAGAGGTGGGGCAGAAGATCCTAGTAAAGAGGAT CCCCTTCAGATAATGGGCCACTTAACAAGTGAAGATGGTGACCATTTTTCTGATGTGCAT TTCGATAGCAAGGTTAAGCAATCTGATCCTGGTAAAATTTCTGAAAAAGGACTCTCTTTT GAAAACGGAAAAGGCCCAGAGCTGGACTCTGTAATGAACAGTGAGAATGATGAACTCAAT GGTGTAAATCAAGTGGTGCCTAAAAAGCGGTGGCAGCGTTTAAACCAAAGGCGCACTAAA CCTCGTAAGCGCATGAACAGATTTAAAGAGAAAGAAAACTCTGAGTGTGCCTTTAGGGTC TTACTTCCTAGTGACCCTGTGCAGGAGGGGCGGGATGAGTTTCCAGAGCATAGAACTCCT TCAGCAAGCATACTTGAGGAACCACTGACAGAGCAAAATCATGCTGACTGCTTAGATTCA GCTGGGCCACGGTTAAATGTTTGTGATAAATCCAGTGCCAGCATTGGTGACATGGAAAAG GAGCCAGGAATTCCCAGTTTGACACCACAGGCTGAGCTCCCTGAACCAGCTGTGCGGTCA GAGAAGAAACGCCTTAGGAAGCCAAGCAAGTGGCTTTTGGAATATACAGAAGAATATGAT CAGATATTTGCTCCTAAGAAAAAACAAAAGAAGGTACAGGAGCAGGTGCACAAGGTAAGT TCCCGCTGTGAAGAGGAAAGCCTTCTAGCCCGAGGTCGATCTAGTGCTCAGAACAAGCAG GTGGACGAGAATTCTTTGATTTCAACCAAAGAAGAGCCTCCAGTTCTTGAAAGGGAGGCT CCGTTTTTGGAGGGCCCCTTGGCTCAGTCAGAACTTGGAGGTGGACATGCTGAGTTGCCG CAGCTGACCTTGTCTGTGCCTGTGGCTCCGGAAGTCTCTCCACGGCCTGCCCTTGAGTCT GAGGAATTGCTAGTTAAAACGCCAGGAAATTATGAAAGTAAACGTCAAAGAAAACCAACT AAGAAACTTCTTGAATCCAATGATTTAGACCCTGGATTTATGCCCAAGAAGGGGGACCTT GGCCTTTCTAAAAAGTGCTATGAAGCTGGTCACCTGGAGAATGGCATAACTGAATCTTGT GCCACATCTTATTCAAAAGATTTTGGTGGAGGCACTACCAAGATATTTGACAAGCCAAGG AAGCGAAAACGACAGAGGCATGCTGCAGCCAAGATGCAGTGTAAAAAAGTGAAAAATGAT GACTCGTCAAAAGAGATTCCAGGCTCAGAGGGAGAACTAATGCCTCACAGGACGGCCACA AGCCCCAAGGAGACTGTTGAGGAAGGTGTAGAACACGATCCCGGGATGCCTGCCTCTAAA AAAATGCAGGGTGAACGCGGTGGAGGAGCTGCACTCAAGGAGAATGTCTGTCAGAATTGT GAAAAATTGGGTGAGCTGCTGTTATGTGAGGCTCAGTGCTGTGGGGCTTTCCACCTGGAG TGCCTTGGATTGACTGAGATGCCAAGAGGAAAATTTATCTGCAATGAATGTCGCACAGGA ATCCATACCTGTTTTGTATGTAAGCAGAGTGGGGAAGATGTTAAAAGGTGCCTTCTACCC TTGTGTGGAAAGTTTTACCATGAAGAGTGTGTCCAGAAGTACCCACCCACTGTTATGCAG AACAAGGGCTTCCGGTGCTCCCTCCACATCTGTATAACCTGTCATGCTGCTAATCCAGCC AATGTTTCTGCATCTAAAGGTCGGTTGATGCGCTGTGTCCGCTGTCCTGTGGCATACCAC GCCAATGACTTTTGCCTGGCTGCTGGGTCAAAGATCCTTGCATCTAATAGTATCATCTGC CCTAATCACTTTACCCCTAGGCGGGGCTGCCGAAATCATGAGCATGTTAATGTTAGCTGG TGCTTTGTGTGCTCAGAAGGAGGCAGCCTTCTGTGCTGTGATTCTTGCCCTGCTGCTTTT CATCGTGAATGCCTGAACATTGATATCCCTGAAGGAAACTGGTATTGCAATGACTGTAAA GCAGGCAAAAAGCCACACTACAGGGAGATTGTCTGGGTAAAAGTTGGACGATACAGGTGG TGGCCAGCTGAGATCTGCCATCCTCGAGCTGTTCCTTCCAACATTGATAAGATGAGACAT GATGTGGGAGAGTTCCCAGTCCTCTTTTTTGGATCTAATGACTATTTGTGGACTCACCAG GCCCGAGTCTTCCCTTACATGGAGGGTGACGTGAGCAGCAAGGATAAGATGGGCAAAGGA GTGGATGGGACATATAAAAAAGCTCTTCAGGAAGCTGCAGCAAGGTTTGAGGAATTAAAG GCCCAAAAAGAGCTAAGACAGCTGCAGGAAGACCGAAAGAATGACAAGAAGCCACCACCT TATAAACATATAAAGGTAAACCGTCCTATTGGCAGGGTACAGATCTTCACTGCAGACTTA TCTGAAATACCCCGTTGCAACTGTAAAGCTACTGATGAGAACCCCTGTGGGATAGACTCT GAATGCATCAACCGCATGCTGCTCTATGAGTGCCACCCCACAGTGTGTCCTGCCGGAGGG CGCTGTCAAAACCAGTGCTTTTCCAAGCGCCAATATCCAGAGGTTGAAATTTTCCGCACA TTACAGCGGGGTTGGGGTCTACGGACAAAAACAGATATTAAAAAGGGTGAATTTGTGAAT GAGTATGTGGGTGAGCTTATAGATGAAGAAGAATGCAGAGCTCGAATTCGCTATGCTCAA GAACATGATATCACTAATTTCTATATGCTCACCCTAGACAAAGACCGAATCATTGATGCT GGTCCCAAAGGAAACTATGCTCGGTTCATGAATCATTGCTGCCAGCCCAACTGTGAAACA CAGAAGTGGTCTGTGAATGGAGATACCCGTGTAGGCCTTTTTGCACTAAGTGACATTAAA GCAGGCACTGAACTTACCTTCAACTACAACCTAGAATGTCTTGGGAATGGAAAGACTGTT TGCAAATGTGGAGCCCCGAACTGCAGTGGCTTCTTGGGTGTAAGGCCAAAGAATCAACCC ATTGCCACGGAAGAAAAGTCAAAGAAATTCAAGAAGAAGCAACAGGGAAAGCGCAGGACC CAGGGTGAAATCACAAAGGAGCGAGAAGATGAGTGTTTTAGTTGTGGGGATGCTGGCCAG CTCGTCTCCTGCAAGAAACCAGGCTGCCCAAAAGTTTACCACGCAGACTGTCTCAATCTG ACCAAGCGACCAGCAGGGAAATGGGAATGTCCGTGGCATCAGTGTGACATCTGCGGGAAG GAAGCAGCCTCCTTCTGTGAGATGTGCCCCAGCTCCTTTTGTAAGCAGCATCGAGAAGGG ATGCTTTTCATTTCCAAACTGGATGGGCGTCTGTCTTGTACTGAGCATGACCCCTGTGGG CCCAATCCTCTGGAACCTGGGGAGATCCGTGAGTATGTGCCTCCCCCAGTACCGCTGCCT CCAGGGCCAAGCACTCACCTGGCAGAGCAATCAACAGGAATGGCTGCTCAGGCACCCAAA ATGTCAGATAAACCTCCTGCTGACACCAACCAGATGCTGTCGCTCTCCAAAAAAGCTCTG GCAGGGACTTGTCAGAGGCCACTGCTACCTGAAAGACCTCTTGAGAGAACTGACTCCAGG CCCCAGCCTTTAGATAAGGTCAGAGACCTCGCTGGGTCAGGGACCAAATCCCAATCCTTG GTTTCCAGCCAGAGGCCACTGGACAGGCCACCAGCAGTGGCAGGACCAAGACCCCAGCTA AGCGACAAACCCTCTCCAGTGACCAGCCCAAGCTCCTCACCCTCAGTCAGGTCCCAACCA CTGGAAAGACCTCTGGGGACGGCTGACCCAAGGCTGGATAAATCCATAGGTGCTGCCAGC CCAAGGCCCCAGTCACTGGAGAAAACCTCAGTTCCCACTGGCCTGAGACTTCCGCCGCCA GACAGACTGCTCATTACTAGCAGTCCCAAACCCCAGACTTCAGACAGGCCTACTGACAAA CCCCATGCCTCTTTGTCCCAGAGACTCCCACCTCCTGAGAAAGTACTATCAGCTGTGGTC CAGACCCTTGTAGCTAAAGAAAAAGCACTGAGGCCTGTGGACCAGAATACTCAGTCAAAA AATAGAGCTGCTTTGGTGATGGATCTCATAGACCTAACTCCTCGCCAGAAGGAGCGGGCA GCTTCACCTCATCAGGTCACACCACAGGCTGATGAGAAGATGCCAGTGTTGGAGTCAAGT TCATGGCCTGCCAGCAAAGGTCTGGGGCATATGCCGAGAGCTGTTGAGAAAGGCTGTGTG TCAGATCCTCTTCAGACATCTGGGAAAGCAGCAGCCCCTTCAGAGGACCCCTGGCAAGCT GTTAAATCACTCACCCAGGCCAGACTTCTTTCTCAGCCTCCTGCCAAGGCCTTTTTATAT GAGCCAACAACTCAGGCCTCAGGAAGAGCTTCTGCAGGGGCTGAGCAGACCCCAGGGCCT CTTAGCCAATCCCCGGGCCTGGTGAAGCAGGCGAAGCAGATGGTCGGAGGCCAGCAACTA CCTGCACTTGCCGCCAAGAGTGGGCAATCTTTTAGGTCTCTCGGGAAGGCCCCAGCCTCC CTCCCCACTGAAGAAAAGAAGTTGGTAACCACAGAGCAAAGTCCCTGGGCCCTGGGAAAA GCCTCATCACGGGCAGGGCTCTGGCCCATAGTGGCTGGACAGACACTGGCACAGTCTTGC TGGTCTGCTGGGAGCACACAGACATTGGCACAGACTTGCTGGTCTCTTGGAAGAGGGCAA GACCCCAAACCAGAGCAAAATACACTTCCAGCTCTTAACCAGGCTCCTTCCAGTCACAAG TGTGCAGAATCAGAACAGAAGTAGTACCAATCAATGTCACATGAACAAACAAGCTGCCCC CAGGGTACCATTTGGGGAGGGGAAATCTTTTCTTTCTTTCCCCCTTAAAAAAAAACACAT CTGCCCCGAACACTTTCCCACTGTTATTCTTTCCTCATATCCCAACACTCAGAACTCTTG TGACATTAGCCAGTGGGGGCTTATGGTTGTGTGAACCATGTATGAAAATCCAGTGGGCCC CAACCAAGGAGACAGACAGACTTGGGTCTCTTTCCCCCAACTTTTCCACATGGTCATCGT GAAATAAAAAGTCCACTCTGGAGTCAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_172349 unedited
NNCGGCCGCGNNAATTCATGCCCCTGNAANACAAGACAGCCCTTTCGGATGATCCAGATT CCAGTACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTT CACAGGAATTGCCATTTTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTG GAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTG ATCCGTTGATTAACACACATTCAAAAATGAAAGTTTCCAACCGGAGGCCCTATCGGCAGT ACTACGTGGAGGCTTTTGGAGATCCTTCTGAGAGAGCCTGGGTGGCTGGAAAAGCAATCG TCATGTTTGAAGGCAGACATCAATTCGAAGAGCTACCTGTCCTTAGGAGAAGAGGGAAAC AGAAAGAAAAAGGATATAGGCATAAGGTTCCTCAGAAAATTTTGAGTAAATGGGAAGCCA GTGTTGGACTTGCAGAACAGTATGATGTTCCCAAGGGGTCAAAGAACCGAANATGTATTC CTGGTTCAATCAAGTTGGACAGTGAAGAAGATATGCCATTTGAAGACTGCACAAATGATC CTGAGTCAGAACATGACCTGTTGCTTAATGGCTGTTTGAAATCACTGGCTTTTGATTCTG AACATTCTGCAGATGAGAAGGAAAAGCCTTGCGCNTAATCTCGAGCCAGAAAGAGCTCTG ATNATCCAAAAAGGACTAGTGTGAAAAAGGGCACATACNATTTGAAGCACATAAAGATGA ACGGGAGGGGAAAGATTCCAGAGAACCNTNGNCCTAAACTTTATCTCTGGGGAATATCTG ATACGCAG >Forward primer walk for NM_172349 unedited
ATNCAAAATAAGACTGCTTTGGTGAAGGAANCTCATANACCTAACTCCTCGCCAGAGGAG CGGGCAGCTTCACCTCATCAGGTCACACCACAGGCTGATGAGAAGATGCCAGTGTTGGAG TCAAGTTCATGGCCTGCCAGCAAAGGTCTGGGGCATATGCCGAGAGCTGTTGAGAAAGGC TGTGTGTCAGATCCTCTTCAGACATCTGGGAAAGCAGCAGCCCCTTCAGAGGACCCCTGG CAAGCTGTTAAATCACTCACCCAGGCCAGACTTCTTTCTCAGCCTCCTGCCAAGGCCTTT TTATATGAGCCAACAACTCAGGCCTCAGGAAGAGCTTCTGCAGGGGCTGAGCAGACCCCA GGGCCTCTTAGCCAATCCCCGGGCCTGGTGAAGCAGGCGAAGCAGATGGTCGGAGGCCAG CAACTACCTGCACTTGCCGCCAAGAGTGGGCAATCTTTTAGGTCTCTCGGGAAGGCCCCA GCCTCCCTCCCCACTGAAGAAAAGAAGTTGGTAACCACAGAGCAAAGTCCCTGGGCCCTG GGAAAAGCCTCATCACGGGCAGGGCTCTGGCCCATAGTGGCTGGACAGACACTGGCACAG TCTTGCTGGTCTGCTGGGAGCACACAGACATTGGCACAGACTTGCTGGTCTCTTGGAAGA AGGCAAGACCCCAAACCAGAGCANAATACACTTCCAGCTCTTAACCAGGCTCCTTCCAGT CACAAGTGTGCAGAATCAGAACAGAGGTAGTACCAATCAATGTCACATGAACAAACAAGC TGCCCCCAGGGTACCATTTTGGGAGGGGAAATCTTTTCTTTCTTTCCCCCTTAAAAAAAA ACACATCTGCCCGAACACTTTCCCAC |
| Restriction Sites | Please inquire |
| ACCN | NM_172349 |
| Insert Size | 7600 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_172349.1, NP_758859.1 |
| RefSeq Size | 7693 bp |
| RefSeq ORF | 7284 bp |
| Locus ID | 64324 |
| UniProt ID | Q96L73 |
| Protein Families | Druggable Genome |
| Protein Pathways | Lysine degradation |
| Gene Summary | This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018] Transcript Variant: This variant (1), also known as ARA267-alpha, differs in the 5' UTR and coding region, compared to variant 2. It encodes a shorter isoform (a), that has a distinct N-terminus compared to isoform b. Variants 1 and 3 both encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. |
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