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Natriuretic Peptide Receptor A (NPR1) (NM_000906) Human Untagged Clone
CAT＃: SC125506
NPR1 (untagged)-Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1)
CNY 7,392.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ANPa; ANPRA; GUC2A; GUCY2A; NPRA |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000906 edited
ATGCCGGGGCCCCGGCGCCCCGCTGGCTCCCGCCTGCGCCTGCTCCTGCTCCTGCTGCTG CCGCCGCTGCTGCTGCTGCTCCGGGGCAGCCACGCGGGCAACCTGACGGTAGCCGTGGTA CTGCCGCTGGCCAATACCTCGTACCCCTGGTCGTGGGCGCGCGTGGGACCCGCCGTGGAG CTGGCCCTGGCCCAGGTGAAGGCGCGCCCCGACTTGCTGCCGGGCTGGACGGTCCGCACG GTGCTGGGCAGCAGCGAAAACGCGCTGGGCGTCTGCTCCGACACCGCAGCGCCCCTGGCC GCGGTGGACCTCAAGTGGGAGCACAACCCCGCTGTGTTCCTGGGCCCCGGCTGCGTGTAC GCCGCCGCCCCAGTGGGGCGCTTCACCGCGCACTGGCGGGTCCCGCTGCTGACCGCCGGC GCCCCGGCGCTGGGCTTCGGTGTCAAGGACGAGTATGCGCTGACCACCCGCGCGGGGCCC AGCTACGCCAAGCTGGGGGACTTCGTGGCGGCGCTGCACCGACGGCTGGGCTGGGAGCGC CAAGCGCTCATGCTCTACGCCTACCGGCCGGGTGACGAAGAGCACTGCTTCTTCCTCGTG GAGGGGCTGTTCATGCGGGTCCGCGACCGCCTCAATATTACGGTGGACCACCTGGAGTTC GCCGAGGACGACCTCAGCCACTACACCAGGCTGCTGCGGACCATGCCGCGCAAAGGCCGA GTTATCTACATCTGCAGCTCCCCTGATGCCTTCAGAACCCTCATGCTCCTGGCCCTGGAA GCTGGCTTGTGTGGGGAGGACTACGTTTTCTTCCACCTGGATATCTTTGGGCAAAGCCTG CAAGGTGGACAGGGCCCTGCTCCCCGCAGGCCCTGGGAGAGAGGGGATGGGCAGGATGTC AGTGCCCGCCAGGCCTTTCAGGCTGCCAAAATCATTACATATAAAGACCCAGATAATCCC GAGTACTTGGAATTCCTGAAGCAGTTAAAACACCTGGCCTATGAGCAGTTCAACTTCACC ATGGAGGATGGCCTGGTGAACACCATCCCAGCATCCTTCCACGACGGGCTCCTGCTCTAT ATCCAGGCAGTGACGGAGACTCTGGCACATGGGGGAACTGTTACTGATGGGGAGAACATC ACTCAGCGGATGTGGAACCGAAGCTTTCAAGGTGTGACAGGATACCTGAAAATTGATAGC AGTGGCGATCGGGAAACAGACTTCTCCCTCTGGGATATGGATCCCGAGAATGGTGCCTTC AGGGTTGTACTGAACTACAATGGGACTTCCCAAGAGCTGGTGGCTGTGTCGGGGCGCAAA CTGAACTGGCCCCTGGGGTACCCTCCTCCTGACATCCCCAAATGTGGCTTTGACAACGAA GACCCAGCATGCAACCAAGATCACCTTTCCACCCTGGAGGTGCTGGCTTTGGTGGGCAGC CTCTCCTTGCTCGGCATTCTGATTGTCTCCTTCTTCATATACAGGAAGATGCAGCTGGAG AAGGAACTGGCCTCGGAGCTGTGGCGGGTGCGCTGGGAGGACGTTGAGCCCAGTAGCCTT GAGAGGCACCTGCGGAGTGCAGGCAGCCGGCTGACCCTGAGCGGGAGAGGCTCCAATTAC GGCTCCCTGCTAACCACAGAGGGCCAGTTCCAAGTCTTTGCCAAGACAGCATATTATAAG GGCAACCTCGTGGCTGTGAAACGTGTGAACCGTAAACGCATTGAGCTGACACGAAAAGTC CTGTTTGAACTGAAGCATATGCGGGATGTGCAGAATGAACACCTGACCAGGTTTGTGGGA GCCTGCACCGACCCCCCCAATATCTGCATCCTCACAGAGTACTGTCCCCGTGGGAGCCTG CAGGACATTCTGGAGAATGAGAGCATCACCCTGGACTGGATGTTCCGGTACTCACTCACC AATGACATCGTCAAGGGCATGCTGTTTCTACACAATGGGGCTATCTGTTCCCATGGGAAC CTCAAGTCATCCAACTGCGTGGTAGATGGGCGCTTTGTGCTCAAGATCACCGACTATGGG CTGGAGAGCTTCAGGGACCTGGACCCAGAGCAAGGACACACCGTTTATGCCAAAAAGCTG TGGACGGCCCCTGAGCTCCTGCGAATGGCTTCACCCCCTGTGCGGGGCTCCCAGGCTGGT GACGTATACAGCTTTGGGATCATCCTTCAGGAGATTGCCCTGAGGAGTGGGGTCTTCCAC GTGGAAGGTTTGGACCTGAGCCCCAAAGAGATCATCGAGCGGGTGACTCGGGGTGAGCAG CCCCCCTTCCGGCCCTCCCTGGCCCTGCAGAGTCACCTGGAGGAGTTGGGGCTGCTCATG CAGCGGTGCTGGGCTGAGGACCCACAGGAGAGGCCACCATTCCAGCAGATCCGCCTGACG TTGCGCAAATTTAACAGGGAGAACAGCAGCAACATCCTGGACAACCTGCTGTCCCGCATG GAGCAGTACGCGAACAATCTGGAGGAACTGGTGGAGGAGCGGACCCAGGCATACCTGGAG GAGAAGCGCAAGGCTGAGGCCCTGCTCTACCAGATCCTGCCTCACTCAGTGGCTGAGCAG CTGAAGCGTGGGGAGACGGTGCAGGCCGAAGCCTTTGACAGTGTTACCATCTACTTCAGT GACATTGTGGGTTTCACAGCGCTGTCGGCGGAGAGCACACCCATGCAGGTGGTGACCCTG CTCAATGACCTGTACACTTGCTTTGATGCTGTCATAGACAACTTTGATGTGTACAAGGTG GAGACAATTGGCGATGCCTACATGGTGGTGTCAGGGCTCCCTGTGCGGAACGGGCGGCTA CACGCCTGCGAGGTAGCCCGCATGGCCCTGGCACTGCTGGATGCTGTGCGCTCCTTCCGA ATCCGCCACCGGCCCCAGGAGCAGCTGCGCTTGCGCATTGGCATCCACACAGGACCTGTG TGTGCTGGAGTGGTGGGACTGAAGATGCCCCGTTACTGTCTCTTTGGGGATACAGTCAAC ACAGCCTCAAGAATGGAGTCTAATGGGGAAGCCCTGAAGATCCACTTGTCTTCTGAGACC AAGGCTGTCCTGGAGGAGTTTGGTGGTTTCGAGCTGGAGCTTCGAGGGGATGTAGAAATG AAGGGCAAAGGCAAGGTTCGGACCTACTGGCTCCTTGGGGAGAGGGGGAGTAGCACCCGA GGCTGA >OriGene 5' read for NM_000906 unedited
ACCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA GCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT TCGGCAGAGGGGAGGCCATGGTAGGAGCGCTCGCCTGCTGCGGTGCCCGCTGAGGCCATG CCGGGGCCCCGGCGCCCCGCTGGCTCCCGCCTGCGCCTGCTCCTGCTCCTGCTGCTGCCG CCGCTGCTGCTGCTGCTCCGGGGCAGCCACGCGGGCAACCTGACGGTAGCCGTGGTACTG CCGCTGGCCAATACCTCGTACCCCTGGTCGTGGGCGCGCGTGGGACCCGCCGTGGAGCTG GCCCTGGCCCAGGTGAAGGCGCGCCCCGACTTGCTGCCGGGCTGGACGGTCCGCACGGTG CTGGGCAGCAGCGAAAACGCGCTGGGCGTCTGCTCCGACACCGCAGCGCCCCTGGCCGCG GTGGACCTCAAGTGGGAGCACAACCCCGCTGTGTTCCTGGGCCCCGGCTGCGTGTACGCC GCCGCCCCAGTGGGGCGCTTCACCGCGCACTGGCGGGTCCCGCTGCTGACCGCCGGCGCC CCGGCGCTGGGCTTCGGTGTCAAGGACGAGTATGCGCTGACCACCCGCGCGGGGCCCAGC TACGCCAAGCTGGGGGACTTCGTGGCGGCGCTGCACCGACGGCTGGGCTGGGAGCGCCAA GCGCTCATGCTCTACGCCTACCGGNCGGGTGACGAAGAGCACTGCTTCTTTCTCGTGGAG GGGCTGTTCATGCNGGTCCGCGACCGNCTCATATTACGGTGGACCACCTGGAGNTCGCCG AGGACGACCTCAGNCACTACACCAGGCTGCTGCNGGACATGCCCGCGCAAGGCCGAGTTA TCTACATCTGCAGCTCCCCTGATGCCTCAGAANCTCATGCTNCTGGCCCTGNAAGCTGCT GTGTGGGAGGACACNT >OriGene 3' read for NM_000906 unedited
CCCGGCAATTGTGAGATTTTAAACGTTCTTTCGCTCATGGTAGNAAGCAAGGCATACAGN GCCCCCAACCCTTCTGCGCCACCCCTCTTCTCCCCTGTGCACTGTGTCTACTGCTGGGTG GAGGGGGTCGGGGGAGCAGGTATTGTGGGCCAGCCCCAGATGTGGGCTCCCCTGCCCTCT CTTCACCTAGTCTCTTTTCATGTTCCCCTTCAGGTGACTCTTTCTCCTCCCAGTAAGTCA CAGGGTAGCAAGGCTGAGGGAGGAGAGCATGGGGAGGGGAGGGGATCAGGAATCCACAGC CCAGCCCGGCCTGAGTCCAGGTGGAGAGCAGGTGCGTGTGCCTGTGTGAGTGTCCCTGTG CATGGCCGTGGGCTTGGCTCAGCCTGTAAGCTCTGAGATCCCCCCATGCCAGTCCCCTCT CAGAGGTCCTATCTGGTGTCTTCACTGGGGTCAGCACACCTGAGCTATTCAAATTACTTC CATCCTTTGGCGATGGGGCTGCTGTGGGTGAGGCTGAGGCCTGGCACCTCTGTTGCTTCT GGCACAGGGTAGGGGAGGTGTGGAGGGATAGGAGAGGAGGCAGGTCAGCCTCGGGTGCTA CTCCCCCTCTCCCCAAGGAGCCAGTAGGTCCGAACCTTGCCTTTGCCCTTCATTTCTACA TCCCCTCGAAGCTCCAGCTCGAAACCACCAAACTCCTCCAGGACAGCCTTGGTCTCAGAA GACAAGTGGATCTTCAGGGCTTCCCCATTAGACTCCATTCTTGAAGCTGTGTTGACTGGA TCCCCAAAGAGACAGTAACCGGGGCATCTTTCAGTCCCACCAATTCAGCACACACAGGTC CTGTGTGGATGCCAATGCGCAAGCGCAACTGCTCCTGGA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000906 |
| Insert Size | 3940 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000906.2, NP_000897.2 |
| RefSeq Size | 4246 bp |
| RefSeq ORF | 3186 bp |
| Locus ID | 4881 |
| UniProt ID | P16066 |
| Domains | pkinase, CYCc, ANF_receptor |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Purine metabolism, Vascular smooth muscle contraction |
| Gene Summary | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A Novel Bioassay for the Activity Determination of Therapeutic Human Brain Natriuretic Peptide (BNP)
,null,
PLoS ONE
,PubMed ID 23185490
[NPR1]
|
|
Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells
,Yuan Li, Padma Madiraju, and Madhu B. Anand-Srivastava,
Cardiovasc Res, Feb 2012; 93: 350 - 359.
[NPR1]
|
|
Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide
,Shunbun Kita, Hitoshi Nishizawa, Yosuke Okuno, Masaki Tanaka, Atsutaka Yasui, Morihiro Matsuda, Yukio Yamada, and Iichiro Shimomura,
J. Endocrinol., May 2009; 201: 287 - 295.
[NPR1]
|
|
Successive Action of Meprin A and Neprilysin Catabolizes B-Type Natriuretic Peptide
,Kristin Pankow, Yong Wang, Florian Gembardt, Eberhard Krause, Xiaoou Sun, Gerd Krause, Heinz-Peter Schultheiss, Wolf-Eberhard Siems, and Thomas Walther,
Circ Res. 2007 Oct 26;101(9):875-82.
[NPR1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209267 | NPR1 (Myc-DDK-tagged)-Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) |
CNY 11,080.00 |
|
| RC209267L1 | Lenti ORF clone of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), Myc-DDK-tagged |
CNY 13,480.00 |
|
| RC209267L2 | Lenti ORF clone of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), mGFP tagged |
CNY 10,260.00 |
|
| RC209267L3 | Lenti ORF clone of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), Myc-DDK-tagged |
CNY 13,480.00 |
|
| RC209267L4 | Lenti ORF clone of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), mGFP tagged |
CNY 13,480.00 |
|
| RG209267 | NPR1 (tGFP-tagged) - Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) |
CNY 12,680.00 |
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