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OTX2 (NM_021728) Human Untagged Clone
CAT＃: SC111661
OTX2 (untagged)-Human orthodenticle homeobox 2 (OTX2), transcript variant 1
CNY 3,600.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPHD6; MCOPS5 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
GCCCTCACTCGCCACATCTACTTTGATAGCTGGCTATTTGGAATTTAAAGGATATTTGACTTTTTCTAAC
CTCCCATGAGGCTGTAAGTTCCACTGCTCCAAACCCACCCACCAAGGACTCTGAACCTGTCCACCCCGGG CGCATCAAGATCTTCCAGCTGGGTACCCCCGATTTGGGCCGACTTTGCACCTCCAAACAACCTTAGCATG ATGTCTTATCTTAAGCAACCGCCTTACGCAGTCAATGGGCTGAGTCTGACCACTTCGGGTATGGACTTGC TGCACCCCTCCGTGGGCTACCCGGGGCCCTGGGCTTCTTGTCCCGCAGCCACCCCCCGGAAACAGCGCCG GGAGAGGACGACGTTCACTCGGGCGCAGCTAGATGTGCTGGAAGCACTGTTTGCCAAGACCCGGTACCCA GACATCTTCATGCGAGAGGAGGTGGCACTGAAAATCAACTTGCCCGAGTCGAGGGTGCAGGTATGGTTTA AGAATCGAAGAGCTAAGTGCCGCCAACAACAGCAACAACAGCAGAATGGAGGTCAAAACAAAGTGAGACC TGCCAAAAAGAAGACATCTCCAGCTCGGGAAGTGAGTTCAGAGAGTGGAACAAGTGGCCAATTCACTCCC CCCTCTAGCACCTCAGTCCCGACCATTGCCAGCAGCAGTGCTCCTGTGTCTATCTGGAGCCCAGCTTCCA TCTCCCCACTGTCAGATCCCTTGTCCACCTCCTCTTCCTGCATGCAGAGGTCCTATCCCATGACCTATAC TCAGGCTTCAGGTTATAGTCAAGGATATGCTGGCTCAACTTCCTACTTTGGGGGCATGGACTGTGGATCA TATTTGACCCCTATGCATCACCAGCTTCCCGGACCAGGGGCCACACTCAGTCCCATGGGTACCAATGCAG TCACCAGCCATCTCAATCAGTCCCCAGCTTCTCTTTCCACCCAGGGATATGGAGCTTCAAGCTTGGGTTT TAACTCAACCACTGATTGCTTGGATTATAAGGACCAAACTGCCTCCTGGAAGCTTAACTTCAATGCTGAC TGCTTGGATTATAAAGATCAGACATCCTCGTGGAAATTCCAGGTTTTGTGAAGACCTGTAGAACCTCTTT TTGTGGGTGATTTTTAAATATACTGGGCTGGACATTCCAGTTTTAGCCAGGCATTGGTTAAAAGAGTTAG ATGGGATGATGCTCAGACTCATCTGATCAAAGTTCCGAGAGGCATAGAAGGAAAAACGAAGGGCCTTAGA GGGGCCTACAAACCAGCAACATGAAATGGACAAACCAATCTGCTTAAGATCCTGTCATAGTTTTAGATCA TTGGTTATCCTGATTTGCAAAGTGATCAAAAGCATTCTAGCCATGTGCAACCAAACACCACCAAAAATAA AATCAAACAAAACTAAGTTGTGAAGGAAGGGAGGGAAGGTCATAGCCTTCTTAAGCAGAGGTGTTCCATT GTTTTAGCCAATCCTTGGTTGAATCTTAGGAATGAACAGTGTCTCAAGCTCATTCACGTTTCATGACCAA CTGGTAGTTGGCACTGAAAAAACTTTTCAGGGCTGTGTGAATTGTGTGACTGATTGTCCTAGATGCACTA CTTTATTTAAAAAATAATGTTCATAAGGAGTCAATATGTAGTTTAAGAGACAATCAGTGTGTGTCTTATA AATGGTACATCTGTGGTTTTTAATCTGTGCTAGACTTCAAAACTGTGATCTCCTGTTATTGTATGCAACC TTGAACTCCACCTCTGCAGGGGTTCTTCTGTGATTAAATAGGTTATAATTATAAGCAAAATTCAGAGCAA CTGAGTACTGATCTAAAAAGATTACCTTTGGCTGGAGGTGAGCTGCACTGAAACTTTACGACAAAATGTC TCTGGMCAAAGAGAGTCAGAGAAGAGAAGCAAAAGGACACTAATTCATCTGTAATTTACTGTTGGTAAGC CTAGCAGTAAAGAGACATTGGTCAATTGCTCTGACCCTGATGAATTATTAAACTGAGATCATTGTCGTTT ATGCTTGCAGATGTTAAATGGAAAAGTTATATATGCATAAACCTTTTCTTCCTGGATTTGGCAGATATGT ATAATTATATTAAAATGGTTCTAGCACAAAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_021728 unedited
CCTCGNGATTTTGTAAACCGNACTTACTGATAGGGCGGACCGCCCAATTCGCACGAGGGC CCTCACTTTCCACATCTACTTTGATAGCTGGCTATTTGGAATTTAAAGGATATTTGACTT TTTCTAACCTCCCATGAGGCTGTAAGTTCCACTGCTCCAAACCCACCCACCAAGGACTCT GAACCTGTCCACCCCGGGCGCATCAAGATCTTCCAGCTTTTTTCCCCCGATTTGGGCCGA CTTTGCACCTCCAAACAACCTTAGCATGATGTCTTATCTTAAGCAACCGCCTTACGCAGT CAATGGGCTGAGTCTGACCACTTCGGGTATGGACTTGCTGCACCCCTCCGTGGGCTACCC GGGGCCCTGGGCTTCTTGTCCCGCAGCCACCCCCCGGAAACAGCGCCGGGAGAGGACGAC GTTCACTCGGGCGCAGCTAGATGTGCTGGAAGCACTGTTTGCCAAGACCCGGTACCCAGA CATCTTCATGCGAGAGGAGGTGGCACTGAAAATCAACTTGCCCGAGTCGAGGGTGCAGGT ATGGTTTAAGAATCGAAGAGCTAAGTGCCGCCAACAACAGCAACAACAGCAGAATGGAGG TCAAAACAAAGTGAGACCTGCCAAAAAGAAGACATCTCCAGCTCGGGAAGTGAGTTCAGA GAGTGGAACAAGTGGCCAATTCACTCCCCCCTCTAGCACCTCAGTCCCGACCATTGCCAG CAGCAGTGCTCCTGTGTCTATCTGGAGCCCAGCTTCCATCTCCCCACTGTCAGATCCCTT GTCCACCTCCTCTTCCTGCATGCAGAGGTCCTATCCCATGACCTATACTCANGCTTCANG TTATAGTCAAGGATATGCTGGCTCAACTTTCTACTTTGNGGCATGGACTGTGNATCATAT TTGACCCCTATGCT >OriGene 3' read for NM_021728 unedited
NGGTACAGATATGNNACCGCGGCCGCATNCNAGNGATCGGTTTTTTTTTTTTTTTTTTTT TTTTTTTGGGCTAGAACCATTTTAATATAATTATACATATCTGCCAAATCCAGGAAAAAA AGTTTATGCATATATAACTTTTCCATTTAACATCTGCAAGCATAAACGACAATGATCTCA GTTTAATAATTCATCAGGGTCAGAGCAATTGACCAATGTCTCTTTACTGCTAGGCTTACC AACAGTAAATTACAGATGAATTAGTGTCCTTTTGCTTCTCTTCTCTGACTCTCTTTGTCC AGAGACATTTTGTCGTAAAGTTTCAGTGCAGCTCACCTCCAGCCAAAGGTAATCTTTTTA GATCAGTACTCAGTTGCTCTGAATTTTGCTTATAATTATAACCTATTTAATCACAGAAGA ACCCCTGCAGAGGTGGAGTTCAAGGTTGCATACAATAACAGGAGATCACAGTTTTGAAGT CTAGCACAGATTAAAAACCACAGATGTACCATTTATAAGACACACACTGATTGTCTCTTA AACTACATATTGACTCCTTATGAACATTATTTTTTAAATAAAGTAGTGCATCTAGGACAA TCAGTCACACAATTCACACAGCCCTGAAAAGTTTTTTCAGTGCCAACTACCAGTTGGTCA TGAAACGTGAATGAGCTTGAGACACTGTTCATTCCTAAGATTCAACCAAGGATTGGCTAA AACAATGGAACACCTCTGCTTAAGAAGGCTATGACCTTCCCTCCCTTCCTTCACAACTTA GTTTTGTTTGATTTTATTTTTGGGTGGTGTTTTGGTTGCACATGGCTAGAATGCTTTTTG ATCACTTTGCNAATCAGGATAACCAATGATCTAAAACTATGACAGGATCTTAAGCAGATG GNTTTGGCCATTTCATGTGCTGGTTTGTGAGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_021728 |
| Insert Size | 2300 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_021728.2, NP_068374.1 |
| RefSeq Size | 2209 bp |
| RefSeq ORF | 894 bp |
| Locus ID | 5015 |
| UniProt ID | P32243 |
| Domains | homeobox, TF_Otx |
| Protein Families | Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Transcription Factors |
| Gene Summary | This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012] Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 5 encode the same protein (isoform a). |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
OTX2 duplications: a recurrent cause of oculo-auriculo-vertebral spectrum.
,null,
Journal of medical genetics
,PubMed ID 36368868
[OTX2]
|
|
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma
,Nagel, S;Ehrentraut, S;Meyer, C;Kaufmann, M;Drexler, HG;MacLeod, RA;,
PLoS ONE
,PubMed ID 26406991
[OTX2]
|
|
Transcriptional and structural control of cell identity genes
,Fan, ZP;,
Thesis
[OTX2]
|
|
OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas
,David C. Adamson, Qun Shi, Matthew Wortham, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, and Hai Yan,
Cancer Res., Jan 2010; 70: 181 - 191
[OTX2]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207479 | OTX2 (Myc-DDK-tagged)-Human orthodenticle homeobox 2 (OTX2), transcript variant 1 |
CNY 3,600.00 |
|
| RC207479L1 | Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1, Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC207479L2 | Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1, mGFP tagged |
CNY 6,000.00 |
|
| RC207479L3 | Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1, Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC207479L4 | Lenti ORF clone of Human orthodenticle homeobox 2 (OTX2), transcript variant 1, mGFP tagged |
CNY 6,000.00 |
|
| RG207479 | OTX2 (tGFP-tagged) - Human orthodenticle homeobox 2 (OTX2), transcript variant 1 |
CNY 5,200.00 |
