United States
Germany
Japan
United Kingdom
China
Tnfrsf21 (NM_178589) Mouse Tagged Lenti ORF Clone
CAT＃: MR209800L4
- LentiORF®
Lenti ORF clone of Tnfrsf21 (mGFP-tagged) - Mouse tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21)
"NM_178589" in other vectors (3)
Need custom modification / cloning service?
Get a free quote
CNY 7,600.00
Product images
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | mGFP |
| Synonyms | AA959878; DR6; R74815; TR7 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| E. coli Selection | Chloramphenicol (34 ug/mL) |
| Mammalian Cell Selection | Puromycin |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209800).
|
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_178589 |
| ORF Size | 1968 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_178589.2, NP_848704.1 |
| RefSeq Size | 3626 bp |
| RefSeq ORF | 1968 bp |
| Locus ID | 94185 |
| UniProt ID | Q9EPU5 |
| Gene Summary | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG209800 | Tnfrsf21 (tGFP-tagged) - Mouse tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21) |
CNY 6,270.00 |
|
| MR209800 | Tnfrsf21 (Myc-DDK-tagged) - Mouse tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21) |
CNY 4,888.00 |
|
| MR209800L3 | Lenti ORF clone of Tnfrsf21 (Myc-DDK-tagged) - Mouse tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21) |
CNY 7,600.00 |
其它Tnfrsf21产品
