HMGCR (NM_000859) Human 3' UTR Clone

Specifications

Product Data
Product Name	HMGCR (NM_000859) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LDLCQ3
ACCN	NM_000859
Insert Size	1792 bp
Sequence Data	Insert Sequence (showhide) >SC216360 3' UTR clone of NM_000859 The sequence shown below is from the reference sequence of NM_000859. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC ACAAGACCTCCAAGGAGCTTGCACCAAGAAGACAGCCTGAATAGCCCGACAGTTCTGAACTGGAACATGG GCATTGGGTTCTAAAGGACTAACATAAAATCTGTGAATTAAAAAAGCTCAATGCATTGTCTTGTGGAGGA TGAATAGATGTGATCACTGAGACAGCCACTTGGTTTTTGGCTCTTTCAGAGAGGTCTCAGGTTCTTTCCA TGCAGACTCCTCAGATCTGAACACAGTTTAGTGCTTTACATGCTGTGCTCTTTGAAGAGATTTCAACAAG AATATTGTATGTTAAAGCATCAGAGATGGTAATCTACAGCTCACCTCTGAAGGCAAATATAAGCTGGGAA AAAAGTTTTGATGAAATTCTTGAAGTTCATGGTGATCAGTGCAATTGACCTTCTCCCTCACTCCTGCCAG TTGAAAATGGATTTTTAAATTATACTGTAGCTGATGAAACTCCTGATTTTGTAGTTAATTTATTAAGTCT GGGATGTAGAACTTCAAGAAGTAAGAGCTAAGTTCTAAGTTCATGTTTGTAAATTAATACTTCATTTGGT GCTGGTCTATTTTGATTTTGGGGGGTAATCAGCATTATTCTTCAGAAGGGGACCTGTTTTCTTCAAGGGA AGAAACACTCTTATTCCCAAACTACAGAATAATGTGTTAAACATGCTAAATAGTTCTATCAGGAAAACAA ATCACTGTATTTATCTCCGCAGGCTATTTGTTCAGAGAGGCCTTTTGTTTAAATATAAATGTTTAAATAT AAATGTTTGTCTGGATTGGCTATAACATGTCTTTCAGCATTAGGCTTTTAAGAAACACAGGGTTTTGTAT TCTTTACTAAAGATATCAGAGCTCTTAATGTTGCTTAGATGAGGGTGACTGTCAAGTACAAGCAAGACTG GGACCTTAGAAATCATTGTAGAAACACAGTTTTGAAAGAAAAATACCATGTCTCTAAGCCAACTTTAATT GCTTAAAAGACATTTTTATTTAGTTGAAAAATCTAGTTTTTTTTGTAAACTGTATCAAATCTGTATATGT TGTAATAAAACTTATGCTAGTTTATTGGAAGTGTTCAAGAAATAAAAATCAACTTGTGTACTGATAAAAT ACTCTAGCCTGGGCCAGAGAAGATAATGTTCTTTAATGTTGTCCAGGAAACCCTGGCTTGCTTGCCGAGC CTAATGAAAGGGAAAGTCAGCTTTCAGAGCCAGTGAAGGAGCCACGTGAATGGCCCTAGAACTGTGCCTA GTTCCTGTGGCCAGGAGGTTGGTGACTGAAACATTCACACAGGGCTCTTTGATGGACCCACGAACGCTCT TAGCTTTCTCAGGGGGTCAGCAGAGTTATTGAATCTTAATTTTTTTTAATGTACAAGTTTTGTATAAATA ATAAAGAACTCCTTATTTTGTATTACATCTAATGCTTCAAGTGTTGCTCTTGGAAAGCTGATGATGTCTC TTGTAGAAGATGGACTCTGAAAAACATTCCAGGAAACCATGGCAGCATGGAGAGCCTCTTAGTGATTGTG TCTGCATTGTTATTGTGGAAGATTTACCTTTTCTGTTGTACGTAAAGCTTAAATTGCTTTTGTTGTGACT TTTTAGCCAGTGACTTTTTCTGAGCTTTTCATGGAAGTGGCAGTGAAAAATATGTTGAGTGTTCATTTTA GTGACTGTAATTAATATCTTGCTGGATTAATGTTTTGTACAATTACTAAATTGTATACATTTTGTTATAG AATACTTTTTTCTAGTTTCAGTAAATAATGAAAAGGAAGTTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000859.2
Synonyms	LDLCQ3
Summary	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Locus ID	3156

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