SIAH1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: LO2 cell, Mouse liver tissue, Mouse kidney tissue lysates IHC: 200-400 Positive control: Human gastric cancer Predicted cell location: Cytoplasm and Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	31 kDa
Gene Name	siah E3 ubiquitin protein ligase 1
Database Link	NP_003022 Entrez Gene 140941 RatEntrez Gene 6477 Human UniProt ID Q8IUQ4
Background	This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Synonyms	SIAH1A
Reference Data
Protein Families	Druggable Genome
Protein Pathways	p53 signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway

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