Caspase 8 (CASP8) Mouse Monoclonal Antibody [Clone ID: 90A992]

Specifications

Product Data
Clone Name	90A992
Applications	CyTOF-ready, FC, IHC, Simple Western, WB
Recommend Dilution	Simple Western: 1:100, Immunohistochemistry-Paraffin: 4 ug/ml, Flow Cytometry: 0.1-0.5 ug/ml, Western Blot: 0.5-2 ug/ml, Immunohistochemistry, CyTOF-ready
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino acids PVETDSEEQP of human Caspase-8 were used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 8
Database Link	NP_203519 Entrez Gene 841 Human UniProt ID Q14790
Background	Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of Caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family.
Synonyms	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis

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