ZAP70 Rabbit Polyclonal Antibody

CAT#: TA333305

Phospho-ZAP70-Y319 Rabbit Polyclonal Antibody



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CNY 2,700.00


货期*
2周

规格
    • 100 ul

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经常一起买 (4)
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Recombinant protein of human zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1, 100 µg
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Specifications

Product Data
Applications IP, WB
Recommend Dilution WB 1:500 - 1:2000
Reactivity Human
Modifications Phospho-specific
Host Rabbit
Clonality Polyclonal
Immunogen A phospho specific peptide corresponding to residues surrounding Y319 of human ZAP70
Formulation Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 619
Gene Name zeta chain of T cell receptor associated protein kinase 70kDa
Background This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Synonyms SRK; STCD; STD; TZK; ZAP-70
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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