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Cyclin A1 (CCNA1) Rabbit Polyclonal Antibody
CAT＃: TA323776S
Anti-CCNA1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: 293T cell lysate IHC: 50-100 Positive control: Human breast cancer Predicted cell location: Nucleus |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to C terminal 300 amino acids of human cyclin A1 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 52 kDa |
| Gene Name | cyclin A1 |
| Database Link | |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family; whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain; as well as in several leukemic cell lines; and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases; which give two distinct kinase activities; one appearing in S phase; the other in G2; and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators; such as Rb family proteins; transcription factor E2F-1; and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | CT146 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation |
Documents
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