Claudin 7 (CLDN7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-3000 WB positive control: Human liver cancer tissue IHC: 50-150 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 199-212 amino acids of Human claudin 7
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kDa
Gene Name	claudin 7
Database Link	NP_001298 Entrez Gene 53624 MouseEntrez Gene 65132 RatEntrez Gene 1366 Human UniProt ID O95471
Background	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets; and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies; including breast cancer; ovarian cancer; hepatocellular carcinomas; urinary tumors; prostate cancer; lung cancer; head and neck cancers; thyroid carcinomas; etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms	CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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