Laminin (LAMA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1606-1620 amino acids of Human laminin, alpha 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	laminin subunit alpha 1
Database Link	NP_005550 Entrez Gene 284217 Human UniProt ID P25391
Background	Laminin subunit alpha-1?is a?protein?that in humans is encoded by the?LAMA1?gene. Laminin is a complex glycoprotein; consisting of three different polypeptide chains (alpha; beta; gamma); which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor; laminin is thought to mediate the attachment; migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Synonyms	LAMA; PTBHS; S-LAM-alpha
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

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