Ubiquitin (UBB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Hela cells and mouse liver tissue IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Nucleus and Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 102-229 amino acids of Human Polyubiquitin-B
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ubiquitin B
Database Link	NP_061828 Entrez Gene 22187 MouseEntrez Gene 192255 RatEntrez Gene 7314 Human UniProt ID P0CG47
Background	This gene encodes ubiquitin; one of the most conserved proteins known. Ubiquitin is required for ATP-dependent; nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded; and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation; suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently; the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.?
Synonyms	HEL-S-50
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Parkinson's disease

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