Jagged1 (JAG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1:20,000 - 1:100,000, WB: 1:500 - 1:2,000, IHC: 1:100 - 1:500, IF: 1:200 - 1:1,000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 110-125 of human Jagged-1protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	jagged 1
Database Link	NP_000205 Entrez Gene 16449 MouseEntrez Gene 182 Human UniProt ID P78504
Synonyms	AGS; AHD; AWS; CD339; HJ1; JAGL1
Note	Anti Jagged 1 Antibody recognizes the jagged 1 protein encoded by the JAG1 gene, that is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signaling through notch 1 has also been shown to play a role in hematopoies.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Notch signaling pathway

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