CDK7 Mouse Monoclonal Antibody [Clone ID: MO-1.1]

Specifications

Product Data
Clone Name	MO-1.1
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	Immunoblotting.  Cell sorting (FACS analysis). Immunofluorescence. Immunoprecipitation of active kinase complex. Immunohistochemistry of Frozen Sections: 1/10-1/20 for 1h at RT.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant C-terminal 221 aa fragment of Human wild-type cdk7/CAK (cyclin activating kinase).
Specificity	Mo-1.1 recognizes the key cell cycle regulator cdk7, which is essential to activate the cdk2 kinase in G1 phase and the cdc2 kinase in G2/M phase.  The antibody is useful for cell cycle analysis, cell proliferation studies and for Immunohistochemistry.
Formulation	PBS, pH 7.4 State: Aff - Purified State: Lyophilized purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.09% Soidum Azide
Reconstitution Method	Restore in 1 ml distilled water
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	cyclin-dependent kinase 7
Database Link	Entrez Gene 1022 Human UniProt ID P50613
Background	Cdk7 is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. Cdk7 forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Synonyms	CAK1, P39 Mo15, STK1, CDK-activating kinase
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Cell cycle, Nucleotide excision repair

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