Gatsl3 (NM_028022) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR204886 protein sequence Red=Cloning site Green=Tags(s) MELHILEHRVRVLSIARPGLWLYTHPLIKLLFLPCRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQ VAEATWLVMNVSHSGSVVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEF QIYREVGGEPVPVTGDDSSNGFPQIQHGPSPTVHPIQSPQNRFCVLTLDPETLPAVATTLIDVLFYSHSV PKEAASGGPESTSIPFFAFSLIEGYISIVMDAEIQRKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIV AQIAGPLAAVDISAYYISTFNFDHALVPEDEIGCVIDILQRRQESQASKDP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	36.6 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_082298
Locus ID	71962
UniProt ID	Q9CWQ8
Refseq Size	1570
Cytogenetics	11 A1
Refseq ORF	996
Synonyms	2410008K03Rik; Castor1
Summary	Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.[UniProtKB/Swiss-Prot Function]

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