C6orf57 (SDHAF4) (NM_145267) Human Mass Spec Standard

Specifications

Product Data
Description	C6orf57 MS Standard C13 and N15-labeled recombinant protein (NP_660310)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205542
Predicted MW	12.2 kDa
Protein Sequence	Sequence Link (showhide) >RC205542 protein sequence Red=Cloning site Green=Tags(s) MTPSRLPWLLSWVSATAWRAARSPLLCHSLRKTSSSQGGKSELVKQSLKKPMLPEGRFDAPEDSHLEKEP LEKFPDDVNPVTKEKGGPRGPEPTRYGDWERKGRCIDF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_660310
RefSeq Size	526
RefSeq ORF	324
Synonyms	C6orf57; Sdh8
Locus ID	135154
Cytogenetics	6q13
Summary	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).[UniProtKB/Swiss-Prot Function]
Protein Families	Secreted Protein

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