Mouse Ptchd4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptchd4
Locus ID	627626
Kit Components	GA218098G1, Ptchd4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA218098G2, Ptchd4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA218098G3, Ptchd4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_028474, NM_001355270
Synonyms	3110082D06Rik; Gm321
Summary	Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.[UniProtKB/Swiss-Prot Function]

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