Mouse Sppl2b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sppl2b
Locus ID	73218
Kit Components	GA209429G1, Sppl2b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209429G2, Sppl2b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209429G3, Sppl2b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_175195, NM_001358803, NM_001358804
Synonyms	3110056O03Rik; AW550292; PSL1
Summary	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.[UniProtKB/Swiss-Prot Function]

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