Mouse Bcor activation kit by CRISPRa
CAT#: GA208838
Bcor CRISPRa kit - CRISPR gene activation of mouse BCL6 interacting corepressor
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Bcor |
Locus ID | 71458 |
Kit Components | GA208838G1, Bcor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208838G2, Bcor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208838G3, Bcor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001168321, NM_029510, NM_175044, NM_175045, NM_175046, NR_045434 |
Synonyms | 2900008C10Rik; 5830466J11Rik; 8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575 |
Summary | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN502120 | Bcor - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |