Human Corticotropin Releasing Factor Receptor 2 (CRHR2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CRHR2
Locus ID	1395
Kit Components	GA100980G1, Corticotropin Releasing Factor Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100980G2, Corticotropin Releasing Factor Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100980G3, Corticotropin Releasing Factor Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001202475, NM_001202481, NM_001202482, NM_001202483, NM_001883
Synonyms	CRF-RB; CRF2; CRFR2; HM-CRF
Summary	The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

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