JHDM1D (KDM7A) (NM_030647) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC218944L1V
- LentiORF®
Lenti ORF particles, KDM7A (Myc-DDK tagged) - Human jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (JHDM1D), 200ul, >10^7 TU/mL
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CNY 16,720.00
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Specifications
Product Data | |
Product Name | JHDM1D (KDM7A) (NM_030647) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | JHDM1D |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_030647 |
ORF Size | 2823 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC218944).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_030647.1 |
RefSeq Size | 9178 bp |
RefSeq ORF | 2826 bp |
Locus ID | 80853 |
MW | 106.4 kDa |
Gene Summary | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.[UniProtKB/Swiss-Prot Function] |
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