DMP1 (NM_004407) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC218741L4V
- LentiORF®
Lenti ORF particles, DMP1 (mGFP-tagged) - Human dentin matrix acidic phosphoprotein 1 (DMP1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
Product Data | |
Product Name | DMP1 (NM_004407) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | ARHP; ARHR; DMP-1 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_004407 |
ORF Size | 1539 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC218741).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004407.1 |
RefSeq Size | 2682 bp |
RefSeq ORF | 1542 bp |
Locus ID | 1758 |
Protein Families | Secreted Protein |
MW | 55.78 kDa |
Gene Summary | Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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