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SARM (SARM1) (NM_015077) Human Untagged Clone
CAT＃: SC318206
SARM1 (untagged)-Human sterile alpha and TIR motif containing 1 (SARM1)
CNY 13,970.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | hSARM1; HsTIR; MyD88-5; SAMD2; SARM |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC318206 representing NM_015077.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGTCCTGACGCTGCTTCTCTCCGCCTACAAGCTGTGTCGCTTCTTCGCCATGTCGGGCCCACGGCCG GGCGCCGAGCGGCTGGCGGTGCCTGGGCCAGATGGGGGCGGTGGCACGGGCCCATGGTGGGCTGCGGGT GGCCGCGGGCCCCGCGAAGTGTCGCCGGGGGCAGGCACCGAGGTGCAGGACGCCCTGGAGCGCGCGCTG CCGGAGCTGCAGCAGGCCTTGTCCGCGCTGAAGCAGGCGGGCGGCGCGCGGGCCGTGGGCGCCGGCCTG GCCGAGGTCTTCCAACTGGTGGAGGAGGCCTGGCTGCTGCCGGCCGTGGGCCGCGAGGTAGCCCAGGGT CTGTGCGACGCCATCCGCCTCGATGGCGGCCTCGACCTGCTGTTGCGGCTGCTGCAGGCGCCGGAGTTG GAGACGCGTGTGCAGGCCGCGCGCCTGCTGGAGCAGATCCTGGTGGCTGAGAACCGAGACCGCGTGGCG CGCATTGGGCTGGGCGTGATCCTGAACCTGGCGAAGGAACGCGAACCCGTAGAGCTGGCGCGGAGCGTG GCAGGCATCTTGGAGCACATGTTCAAGCATTCGGAGGAGACATGCCAGAGGCTGGTGGCGGCCGGCGGC CTGGACGCGGTGCTGTATTGGTGCCGCCGCACGGACCCCGCGCTGCTGCGCCACTGCGCGCTGGCGCTG GGCAACTGCGCGCTGCACGGGGGCCAGGCGGTGCAGCGACGCATGGTAGAGAAGCGCGCAGCCGAGTGG CTCTTCCCGCTCGCCTTCTCCAAGGAGGACGAGCTGCTTCGGCTGCACGCCTGCCTCGCAGTAGCGGTG TTGGCGACTAACAAGGAGGTGGAGCGCGAGGTGGAGCGCTCGGGCACGCTGGCGCTCGTGGAGCCGCTT GTGGCCTCGCTGGACCCTGGCCGCTTCGCCCGCTGTCTGGTGGACGCCAGCGACACAAGCCAGGGCCGC GGGCCCGACGACCTGCAGCGCCTCGTGCCGTTGCTCGACTCTAACCGCTTGGAGGCGCAGTGCATCGGG GCTTTCTACCTCTGCGCCGAGGCTGCCATCAAGAGCCTGCAAGGCAAGACCAAGGTGTTCAGCGACATC GGCGCCATCCAGAGCCTGAAACGCCTGGTTTCCTACTCTACCAATGGCACTAAGTCGGCGCTGGCCAAG CGCGCGCTGCGCCTGCTGGGCGAGGAGGTGCCACGGCCCATCCTGCCCTCCGTGCCCAGCTGGAAGGAG GCCGAGGTTCAGACGTGGCTGCAGCAGATCGGTTTCTCCAAGTACTGCGAGAGCTTCCGGGAGCAGCAG GTGGATGGCGACCTGCTTCTGCGGCTCACGGAGGAGGAACTCCAGACCGACCTGGGCATGAAATCGGGC ATCACCCGCAAGAGGTTCTTTAGGGAGCTCACGGAGCTCAAGACCTTCGCCAACTATTCTACGTGCGAC CGCAGCAACCTGGCGGACTGGCTGGGCAGCCTGGACCCGCGCTTCCGCCAGTACACCTACGGCCTGGTC AGCTGCGGCCTGGACCGCTCCCTGCTGCACCGCGTGTCTGAGCAGCAGCTGCTGGAAGACTGCGGCATC CACCTGGGCGTGCACCGCGCCCGCATCCTCACGGCGGCCAGAGAAATGCTACACTCCCCGCTGCCCTGT ACTGGTGGCAAACCCAGTGGGGACACTCCAGATGTCTTCATCAGCTACCGCCGGAACTCAGGTTCCCAG CTGGCCAGTCTCCTGAAGGTGCACCTGCAGCTGCATGGCTTCAGTGTCTTCATTGATGTGGAGAAGCTG GAAGCAGGCAAGTTCGAGGACAAACTCATCCAGAGTGTCATGGGTGCCCGCAACTTTGTGTTGGTGCTA TCACCTGGAGCACTGGACAAGTGCATGCAAGACCATGACTGCAAGGATTGGGTGCATAAGGAGATTGTG ACTGCTTTAAGCTGCGGCAAGAACATTGTGCCCATCATTGATGGCTTCGAGTGGCCTGAGCCCCAGGTC CTGCCTGAGGACATGCAGGCTGTGCTTACTTTCAACGGTATCAAGTGGTCCCACGAATACCAGGAGGCC ACCATTGAGAAGATCATCCGCTTCCTGCAGGGCCGCTCCTCCCGGGACTCATCTGCAGGCTCTGACACC AGTTTGGAGGGTGCTGCACCCATGGGTCCAACCTAA AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGAT ATCCTGGATTACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-RsrII |
| ACCN | NM_015077 |
| Insert Size | 2175 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015077.3 |
| RefSeq Size | 7305 bp |
| RefSeq ORF | 2175 bp |
| Locus ID | 23098 |
| UniProt ID | Q6SZW1 |
| Domains | TIR, SAM |
| Protein Families | Druggable Genome |
| MW | 79.4 kDa |
| Gene Summary | Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function] |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215903 | SARM1 (Myc-DDK-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 5,304.00 |
|
| RC215903L1 | Lenti-ORF clone of SARM1 (Myc-DDK-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 7,704.00 |
|
| RC215903L2 | Lenti-ORF clone of SARM1 (mGFP-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 7,704.00 |
|
| RC215903L3 | Lenti-ORF clone of SARM1 (Myc-DDK-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 9,600.00 |
|
| RC215903L4 | Lenti-ORF clone of SARM1 (mGFP-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 7,704.00 |
|
| RG215903 | SARM1 (tGFP-tagged) - Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 6,904.00 |
|
| SC108546 | SARM1 (untagged)-Human sterile alpha and TIR motif containing 1 (SARM1) |
CNY 5,064.00 |
