RNF170 (BC032393) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	DKFZP564A022
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC032393 edited GACGTCTAGTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTC TGTCGCCGGGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATA TCAAGGTGAAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGA CCAAGTACTTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACT TTTCAGAAATGTACATCAAAACATTCACCCAGAAAACCAGGAGCTAGTAAGGGTACTTCG AGAACAGCTTCAAACAGAACAGGATGCACCTGCTGCCACTCGACAGCAGTTCTACACTGA CATGTACTGTCCCATCTGCCTGCACCAAGCCTCCTTCCCGGTGGAGACCAACTGTGGACA TCTTTTTTGTGGTGCCTGCATTATTGCTTACTGGCGATATGGTTCATGGCTTGGGGCAAT CAGTTGTCCAATCTGTAGACAAACGGGTTCATCAGAGAAGAGCAGCCGTGCAAGTGAGCA GACCCATCAAGAGGCTGTTGCATGCCTGGACACACAGAACTCTCCTGCCTGTACAGTCGG ATGCAGGTCAGGGCCTCAGCATATACCCCATGACCGAATGCTCCCTTCAGCCTCACCACG TTTATGCTTCACGTTACTAGACTGTGTTTCCATCCTTTGGTTCTCAGGTTAAATGTTCCC TCCTCACTCAGACTACCCAAAAGTAGGCAGTGCAAAAGTAGTGCAAAAGTAGGCAGTGAC CCTCCCCTCCCCTTACCCCAGGGCACTCTGAGGCATTCAGACATCTCAGCACAGCATCAT CATATTGACATTTCCATTGTCTGTCTGCTTCTCACTAGAACACAAGCTCTATGAAAACAG AGACAATGTTAGTTTTGTCCACCCAGATATTCACAGATGTACCGTTATGCCTGCCACCAC AGTAGTGCTCAACACATTAAAGATTAATAAATAAAGCAAGGGAAAGACAGGAAAGGGCAG AAGACAAGGAAAGATCACTTCTTACTCAGTCATGGCTGCCGCCCAGGTCTAAGCCACCCT CACTTCTCACCTAAAGGATCACAGCGACCTTCCAGGCAGTCTCCCAGGCACCAAGTGCCT GGCTCCCTACATGCAACGCAGCCCGATGATCATCTCAAGTGTGACTCTGCTGGAAAGCCT GCTCTCCCTTTCCCACAGAGTAAAGGTAAAGTCCTCACGCCAGCCTGCAAGGCCCCATGT GACCTTGGTTGCTCATTTCCTCTCTAACCTCATCTCACATTTGTCCCCACAGCTCACTCT GCTCCAGCCATCCAGCCCTCCTTGCTGTCCTTTGAGCAGGCTGAAGACGCCCAGCCTCAG GAGCTCTGCCCTGGCCAGTCCCTCTGACTGCTAGGCTCCTCCGCCGGGCATCCTCACAGC CAACTCTCACCAACTCCAGATCTTCGCACAATAGCCATTTCCTCTGTTAGGCCTGTCCTG TCCACCATAAGGAAACTTGCAACTCCCTCAGCCCACAGAGCACCTCTCACCGGCTAACAT ACTCTGTGGTCACGTGTTTGCTATCTGCCTCCCTAATGTCTTTGAGAACATTAGCTCCCT GAGGGCAGAAATCTCCTTCACTGACATATCCCAAGCCCCCAGAACTATGCGTGCAGCATA GTCAGTAACTATTTGTTGAATCAATGAATGAGAAAACAATATCAGGGAACTCTAAGTTGA AATACACTTTCTCAGTTCACAATGTTATCCATTCTGACCTTTATCAGACACAGGCACAGA GGACCTCAGAGATATTCCCAGCAGTCTCAATATCCATGGTAATGCTAATAAACTACTATT CTGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC032393 unedited TTGGGATTTGTAATACGACTCTACTATAGGGCGGCCGCGGAATTCCCGGGGAGACGTCTA GTGGGTTGCCCGGGAGGGGTGGCGGGAGCGGTCCTGGAAATAATCTGTCCTCTGTCGCCG GGAACTGGCGAGGTAGTTCCTTCGCGGTGGAGAGACCTGGAATGGCCAAATATCAAGGTG AAGTTCAAAGTTTGAAACTGGATGATGATTCAGTTATAGAAGGAGTAAGCGACCAAGTAC TTGTGGCAGTTGTGGTCAGTTTCGCTTTGATTGCTACCCTGGTATATGCACTTTTCAGAA ATGTACATCAAAACATTCACCCAGAAAACCAGGAGCTAGTAAGGGTACTTCGAGAACAGC TTCAAACAGAACAGGATGCACCTGCTGCCACTCGACAGCAGTTCTACACTGACATGTACT GTCCCATCTGCCTGCACCAAGCCTCCTTCCCGGTGGAGACCAACTGTGGACATCTTTTTT GTGGTGCCTGCATTATTGCTTACTGGCGATATGGTTCATGGCTTGAGGCAATCAGTTGTC CAATCTGTAGACAAACGGGTTCATCAGAAGAAAGCAGCCGTGCAAGTGAGCAGACCCATC AAGAGGCTGTTGCATGCCTGGACACACAGAACTCTCCTGCCTGTACAGTCCGATGCAGGT TAGGGCCTCACCATATACCCCATGACCCGATGCTCCCTTCAACCTCACACGTTTATGCTT CACGTTACTAGACTGTGTTTCCATCCTTTGGTCTCAAGTTAAATGTTCCCTCCTCATTCA ACTACCCAAAATGAGGCGGGGCANAAGTAGTGCCAAAGTAGGCAGGGACCCCTCCCTCCC CTTAACCCAAGGGACTTTTGAGGCATTTAAAATTCTGAGCACAGAATCATTATATTGGAC ATTTCCATTGGCGCGCCGGCCTCTTACACAAACAAAAAGCCCT
Restriction Sites	Please inquire
ACCN	BC032393
Insert Size	1954 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC032393.1, AAH32393.1
RefSeq Size	1954 bp
Locus ID	81790
Protein Families	Druggable Genome, Transmembrane
Gene Summary	This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

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