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GGCX (NM_000821) Human Untagged Clone
CAT＃: SC119634
GGCX (untagged)-Human gamma-glutamyl carboxylase (GGCX), transcript variant 1
CNY 5,560.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | VKCFD1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119634 sequence for NM_000821 edited (data generated by NextGen Sequencing)
ATGGCGGTGTCTGCCGGGTCCGCGCGGACCTCGCCCAGCTCAGATAAAGTACAGAAAGAC AAGGCTGAACTGATCTCAGGGCCCAGGCAGGACAGCCGAATAGGGAAACTCTTGGGTTTT GAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACCCTGCTGAATCGACCAACGGAC CCTGCAAGCTTAGCTGTCTTTCGTTTTCTTTTTGGGTTCTTGATGGTGCTAGACATTCCC CAGGAGCGGGGGCTCAGCTCTCTGGACCGGAAATACCTTGATGGGCTGGATGTGTGCCGC TTCCCCTTGCTGGATGCCCTACGCCCACTGCCACTTGACTGGATGTATCTTGTCTACACC ATCATGTTTCTGGGGGCACTGGGCATGATGCTGGGCCTGTGCTACCGGATAAGCTGTGTG TTATTCCTGCTGCCATACTGGTATGTGTTTCTCCTGGACAAGACATCATGGAACAACCAC TCCTATCTGTATGGGTTGTTGGCCTTTCAGCTAACATTCATGGATGCAAACCACTACTGG TCTGTGGACGGTCTGCTGAATGCCCATAGGAGGAATGCCCACGTGCCCCTTTGGAACTAT GCAGTGCTCCGTGGCCAGATCTTCATTGTGTACTTCATTGCGGGTGTGAAAAAGCTGGAT GCAGACTGGGTTGAAGGCTATTCCATGGAATATTTGTCCCGGCACTGGCTCTTCAGTCCC TTCAAACTGCTGTTGTCTGAGGAGCTGACTAGCCTGCTGGTCGTGCACTGGGGTGGGCTG CTGCTTGACCTCTCAGCTGGTTTCCTGCTCTTTTTTGATGTCTCAAGATCCATTGGCCTG TTCTTTGTGTCCTACTTCCACTGCATGAATTCCCAGCTTTTCAGCATTGGTATGTTCTCC TACGTCATGCTGGCCAGCAGCCCTCTCTTCTGCTCCCCTGAGTGGCCTCGGAAGCTGGTG TCCTACTGCCCCCAAAGGTTGCAACAACTGTTGCCCCTCAAGGCAGCCCCTCAGCCCAGT GTTTCCTGTGTGTATAAGAGGAGCCGGGGCAAAAGTGGCCAGAAGCCAGGGCTGCGCCAT CAGCTGGGAGCTGCCTTCACCCTGCTCTACCTCCTGGAGCAGCTATTCCTGCCCTATTCT CATTTTCTCACCCAGGGCTATAACAACTGGACAAATGGGCTGTATGGCTATTCCTGGGAC ATGATGGTGCACTCCCGTTCCCACCAGCACGTGAAGATCACCTACCGTGATGGCCGCACT GGCGAACTGGGCTACCTTAACCCTGGGGTATTTACACAGAGTCGGCGATGGAAGGATCAT GCAGACATGCTGAAGCAATATGCCACTTGCCTGAGCCGCCTGCTTCCCAAGTATAATGTC ACTGAGCCCCAGATCTACTTTGATATTTGGGTCTCCATCAATGACCGCTTCCAGCAGAGG ATTTTTGACCCTCGTGTGGACATCGTGCAGGCCGCTTGGTCACCCTTTCAGCGCACATCC TGGGTGCAACCACTCTTGATGGACCTGTCTCCCTGGAGGGCCAAGTTACAGGAAATCAAG AGCAGCCTAGACAACCACACTGAGGTGGTCTTCATTGCAGATTTCCCTGGACTGCACTTG GAGAATTTTGTGAGTGAAGACCTGGGCAACACTAGCATCCAGCTGCTGCAGGGGGAAGTG ACTGTGGAGCTTGTGGCAGAACAGAAGAACCAGACTCTTCGAGAGGGAGAAAAAATGCAG TTGCCTGCTGGTGAGTACCATAAGGTGTATACGACATCACCTAGCCCTTCTTGCTACATG TACGTCTATGTCAACACTACAGAGCTTGCACTGGAGCAAGACCTGGCATATCTGCAAGAA TTAAAGGAAAAGGTGGAGAATGGAAGTGAAACAGGGCCTCTACCCCCAGAGCTGCAGCCT CTGTTGGAAGGGGAAGTAAAAGGGGGCCCTGAGCCAACACCTCTGGTTCAGACCTTTCTT AGACGCCAACAAAGGCTCCAGGAGATTGAACGCCGGCGAAATACTCCTTTCCATGAGCGA TTCTTCCGCTTCTTGTTGCGAAAGCTCTATGTCTTTCGCCGCAGCTTCCTGATGACTTGT ATCTCACTTCGAAATCTGATATTAGGCCGTCCTTCCCTGGAGCAGCTGGCCCAGGAGGTG ACTTATGCAAACTTGAGACCCTTTGAGGCAGTTGGAGAACTGAATCCCTCAAACACGGAT TCTTCACATTCTAATCCTCCTGAGTCAAATCCTGATCCTGTCCACTCAGAGTTCTGA Clone variation with respect to NM_000821.5 974 g=>a;1218 c=>t >OriGene 5' read for NM_000821 unedited
NGTTTCAGCATTTTGTAATACGACTCACTTATAGGGCGGCCGCGATTCGGCACGAGGCCC ACCTGCCTCCTCCGCAGAGCAATGGCGGTGTCTGCCGGGTCCGCGCGGACCTCGCCCAGC TCAGATAAAGTACAGAAAGACAAGGCTGAACTGATCTCAGGGCCCAGGCAGGACAGCCGA ATAGGGAAACTCTTGGGTTTTGAGTGGACAGATTTGTCCAGTTGGCGGAGGCTGGTGACC CTGCTGAATCGACCAACGGACCCTGCAAGCTTAGCTGTCTTTCGTTTTCTTTTTGGGTTC TTGATGGTGCTAGACATTCCCCAGGAGCGGGGGCTCAGCTCTCTGGACCGGAAATACCTT GATGGGCTGGATGTGTGCCGCTTCCCCTTGCTGGATGCCCTACGCCCACTGCCACTTGAC TGGATGTATCTTGTCTACACCATCATGTTTCTGGGGGCACTGGGCATGATGCTGGGCCTG TGCTACCGGATAAGCTGTGTGTTATTCCTGCTGCCATACTGGTATGTGTTTCTCCTGGAC AAGACATCATGGAACAACCACTCCTATCTGTATGGGTTGTTGGCCTTTCAGCTAACATTC ATGGATGCAAACCACTACTGGTCTGTGGACGGTCTGCTGAATGCCCATAGGAGGAATGCC CACGTGCCCCTTTGGAACTATGCAGTGCTCCGTGGCCAGATCTTCATTGTGTACTTCATT GCGGGTGTGAAAAAGCTGGATGCAGACTGGGTTGAAGCTATTCCATGGAATAATTGTCCC GCACTGGCTCTTCAGTCCCTTCAACTGCTGTTGTCTGAAGAGCTGACTANCCTGCTGTTC GTGCACTGGGGTGGGCTGCTGCTTGACCTCTCAGCTGGTTTCTGCTCTTTNTTGATGCTC AAGACCATTGGCCTGTCTTTGGGCCTACTTCCA >OriGene 3' read for NM_000821 unedited
CTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGCCACTTTAT TTATTTATTTATTTTGAGACGAAGTCTTGCTCTGTTGCCCAGGAGTGCAGTGGCTCGATC TCGGCTCACTGCAACCTCCACCTCCTGGGCCCAAGCGATTCTCATGCCTCAGCCTCCTGG GTAGTTGGATTACAGGCACCCACCACCACGTCTGGCTAATTTTTGTATTTTTAGTAGAGA AGGGGTCTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCTGCCCA CCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACGGCACCCAGCCCCCAAAAA GCCACTTTAAACCTTATCCTAGGAGGACAGTTTCACATTGCGTCTAACCTCTTCCTGGCC TCTTAATCTTGGGTTGTTAAATCTTATTTGCTTTATTTCCTTGGTTCCTCTAAGTTGTAA TCTCGGAGTTAAAAACAGCTTTAGAACCCCGCCCCCCCAAAAAAAAAAAAAAAAACTTTT GAGAATTTTTTTCAAATAAATGTCCATTGCATAGAATGGGTCTGTGACTGGCTGCTTCTA CATCTGCACCCAACATCTGGCCCCCTTCAGAACTCTGAGTGGACAGGATCAGGATTTGAC TCANGAGGATTAGAATGTGAAGAATCCGTGTTTGAGGGATTCAGTTCTCCAACTGCCTCA AAGGGTCTCAAGTTTGCATAAGTCACCTCCTGGGCCAGCTGCCTCCAGGAAGGACGGCCT AATATCAGATTTCGAAGTGAGATACAAGTCATCAGGAACCTGCGGCGAAAGAATAGAGCT TTCGCAACAGAAGCGGAGAATCGCTCATGGAAAGGAGTATTTTCGCCGCGTTCATCTCCT GGAGCCTTTGTTGCGTCTAAGAAAGTCTGACCAGAGGGTTGCCTCAGGNCCCCCTAACTT CCCTCCACAGAGCTGCGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000821 |
| Insert Size | 2940 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000821.3, NP_000812.2 |
| RefSeq Size | 3236 bp |
| RefSeq ORF | 2277 bp |
| Locus ID | 2677 |
| UniProt ID | P38435 |
| Domains | VKG_Carbox |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The role of phosphatidylserine receptors in enveloped virus infection
,Morizono, K;Chen, IS;,
J. Virol., Jan 2014.
,PubMed ID 24478428
[GGCX]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204003 | GGCX (Myc-DDK-tagged)-Human gamma-glutamyl carboxylase (GGCX), transcript variant 1 |
CNY 5,552.00 |
|
| RC204003L3 | Lenti ORF clone of Human gamma-glutamyl carboxylase (GGCX), transcript variant 1, Myc-DDK-tagged |
CNY 7,700.00 |
|
| RC204003L4 | Lenti ORF clone of Human gamma-glutamyl carboxylase (GGCX), transcript variant 1, mGFP tagged |
CNY 7,700.00 |
|
| RG204003 | GGCX (tGFP-tagged) - Human gamma-glutamyl carboxylase (GGCX), transcript variant 1 |
CNY 7,152.00 |
|
| SC320393 | GGCX (untagged)-Human gamma-glutamyl carboxylase (GGCX), transcript variant 1 |
CNY 5,560.00 |
