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DOCK2 (NM_004946) Human Untagged Clone
CAT＃: SC107268
DOCK2 (untagged)-Human dedicator of cytokinesis 2 (DOCK2)
CNY 12,312.00
货期*
现货
规格
Product images
经常一起买 (4)
DOCK2 mouse monoclonal antibody, clone OTI7G2 (formerly 7G2)
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IMD40 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004946, the custom clone sequence may differ by one or more nucleotides
ATGGCCCCCTGGCGCAAAGCTGACAAGGAGCGGCACGGCGTGGCCATATACAACTTCCAAGGCAGCGGAG CCCCCCAGCTCTCCCTGCAGATCGGCGATGTGGTGCGAATACAGGAGACGTGTGGAGACTGGTATAGGGG ATACCTCATAAAGCACAAAATGTTACAGGGCATTTTTCCTAAGTCATTTATCCACATCAAGGAAGTGACA GTTGAGAAAAGAAGAAATACTGAGAACATCATTCCTGCAGAAATTCCTCTGGCACAAGAAGTGACAACGA CACTTTGGGAATGGGGAAGCATCTGGAAACAACTCTATGTGGCCAGCAAAAAGGAGCGTTTTCTCCAGGT GCAGTCCATGATGTACGATCTGATGGAGTGGAGGTCCCAGCTTCTCTCAGGAACCTTACCCAAGGATGAG CTGAAGGAACTGAAGCAGAAAGTCACGTCCAAAATTGACTATGGCAACAAAATCCTTGAGCTTGATTTGA TTGTCAGAGATGAAGACGGAAATATCTTGGACCCTGATAATACCAGTGTCATCAGCTTGTTCCATGCACA TGAGGAAGCAACTGATAAAATCACAGAGCGTATCAAAGAAGAAATGTCAAAAGACCAGCCAGATTATGCA ATGTATTCCCGGATCTCCTCATCCCCCACCCATAGCCTCTATGTGTTTGTGAGAAACTTTGTGTGCAGAA TTGGGGAAGATGCTGAGCTCTTCATGTCTCTCTACGACCCCAACAAGCAAACGGTCATAAGTGAGAACTA CCTAGTGCGATGGGGCAGCCGGGGCTTCCCTAAGGAGATTGAGATGCTCAACAATCTGAAGGTGGTCTTC ACGGATCTTGGAAACAAAGACCTCAACAGGGATAAAATTTACTTGATTTGTCAAATAGTCCGGGTCGGCA AGATGGATCTTAAGGATACTGGTGCAAAGAAGTGCACGCAGGGACTGAGGAGGCCCTTTGGGGTGGCAGT TATGGATATAACAGACATCATCAAGGGGAAAGCAGAGAGTGATGAAGAAAAGCAGCACTTCATTCCTTTT CACCCGGTTACAGCTGAGAATGACTTCCTACACAGCCTGCTGGGCAAAGTCATAGCCTCCAAGGGGGACA GTGGAGGGCAAGGCCTCTGGGTGACCATGAAGATGCTGGTGGGTGACATCATTCAGATTCGCAAGGACTA TCCACACCTGGTGGACAGGACCACCGTGGTGGCCAGGAAGCTGGGATTCCCAGAGATCATCATGCCAGGG GATGTCAGGAACGACATCTACATTACTCTCTTACAAGGTGACTTTGACAAGTACAACAAGACCACACAGA GGAATGTGGAAGTCATCATGTGTGTGTGCGCGGAGGATGGCAAAACGCTGCCTAATGCAATTTGCGTGGG AGCAGGGGACAAGCCCATGAATGAGTATCGCTCCGTTGTGTACTATCAAGTCAAACAGCCACGCTGGATG GAAACAGTCAAGGTGGCTGTCCCTATTGAAGACATGCAGAGGATCCATCTGCGATTCATGTTTCGACATC GGTCATCTCTGGAATCTAAAGATAAAGGAGAAAAGAACTTTGCCATGTCCTATGTGAAGCTGATGAAAGA AGATGGGACTACTCTACACGATGGATTCCATGACTTAGTTGTCCTCAAGGGGGACAGCAAGAAGATGGAG GATGCCAGCGCATACCTGACCCTTCCTTCTTATCGACACCATGTGGAAAACAAGGGGGCCACGCTGAGCA GGAGCTCCAGCAGTGTTGGGGGGCTTTCTGTCAGCTCCCGGGATGTGTTCTCCATTTCCACCCTGGTGTG CTCCACAAAGCTCACTCAGAATGTGGGCTTGCTGGGTTTGCTGAAGTGGCGTATGAAGCCTCAACTGCTA CAGGAGAATTTAGAAAAGTTGAAGATTGTGGATGGAGAGGAAGTGGTGAAGTTTCTCCAGGATACTCTGG ATGCCCTCTTCAACATCATGATGGAGCATTCTCAAAGTGATGAATATGACATCCTCGTCTTTGATGCCTT GATTTACATAATAGGACTCATTGCAGACCGGAAATTTCAGCATTTCAACACCGTTCTGGAGGCTTACATC CAACAGCATTTCAGTGCGACCTTGGCTTACAAGAAATTGATGACAGTGCTGAAGACTTACTTGGATACCT CCAGCAGAGGGGAGCAATGTGAGCCAATCCTAAGAACGCTGAAGGCTTTGGAATATGTGTTCAAGTTCAT TGTTCGGTCGAGGACATTATTTTCACAGCTTTATGAAGGCAAAGAACAGATGGAGTTTGAAGAATCCATG AGACGGCTCTTTGAATCCATCAACAATCTGATGAAAAGTCAATACAAAACTACCATCCTTTTGCAGGTGG CGGCTTTGAAATACATCCCATCTGTCCTGCATGATGTAGAAATGGTCTTTGATGCGAAGTTACTCAGCCA ACTCCTGTATGAGTTCTACACCTGCATCCCTCCTGTGAAACTCCAGAAGCAGAAAGTACAGTCTATGAAT GAGATAGTCCAGAGCAACCTCTTTAAAAAGCAAGAATGCCGGGACATTCTGCTTCCTGTCATCACCAAAG AGCTGAAGGAGCTGCTGGAGCAGAAGGATGACATGCAACACCAGGTCCTGGAGAGGAAGTACTGCGTTGA ATTGCTCAACAGCATCTTGGAAGTCCTTAGCTACCAGGATGCGGCCTTCACCTACCACCATATCCAGGAG ATCATGGTCCAGCTGCTGCGGACAGTGAACCGGACAGTCATCACCATGGGCCGGGATCACATTCTGATTA GTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACTACTCCTTCTACATTGA GACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATT GGAAAGAACGTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTA TCAACAAGTTTGCAGAAACCATGAACCAGAAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAA CAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTCTGCAGCTGGAGCAGTTCTCACACGCC AAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTGATATGT GGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACT TATCCCTGAGGCTGAGCTCCGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAA AGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAATCATCCTGAAGCTGGACCACGAGGTAGAAGGGGGCC GAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTGCAGAGCACCCAACCAT TGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGT GTGATGACAGATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATA ACAACAGGGAGGAGATGTACATAAGGTACCTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTA CACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCAAGTGGTCGGATGAGCAGTGTGCATCA CAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACGAGACCA TCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACA GTACGAGATGGAGATCTTTGACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAA AGCATCATGAAAATCCTCAGGCCCAAACCAGACTACTTTGCTGTTGGATACTACGGCCAGGGATTCCCCT CCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAGAAGATTTCCAGATGCA GCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAAT GCCCCAGGCCAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATA AGCCAGTGCCTGACCAGATTATAAACTTCTACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCC CGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCATGTGGATTGAGAGAACCTCCTTCGTG ACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAATTAGTC CTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCA GAGTGATGAGACCCTCCCCATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATG GGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCACTGAAGAGTATGTCAGGGACCACCCTGAGGACCAGG ACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCA TGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAA ATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCA GGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCAC CCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAG GAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGA GAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCA TGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAA ATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGT TGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGAC ACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAA CAGATCCCAGACTCGCTGTCCACGGACCTGTGA >OriGene 5' read for NM_004946 unedited
CGCGAATTCGGCACCAGGAAAAGAGGAAGGAAGTGGGGCCCTGCGGCGCCCAGCCACCCC CTGACGGCTTCCCCACGGGAGGACGCGAGGCCCCGGCCCAGCCATGGCCCCCTGGCGCAA AGCTGACAAGGAGCGGCACGGCGTGGCCATATACAACTTCCAAGGCAGCGGAGCCCCCCA GCTCTCCCTGCAGATCGGCGATGTGGTGCGAATACAGGAGACGTGTGGAGACTGGTATAG GGGATACCTCATAAAGCACAAAATGTTACAGGGCATTTTTCCTAAGTCATTTATCCACAT CAAGGAAGTGACAGTTGAGAAAAGAAGAAATACTGAGAACATCATTCCTGCAGAAATTCC TCTGGCACAAGAAGTGACAACGACACTTTGGGAATGGGGAAGCATCTGGAAACAACTCTA TGTGGCCAGCAAAAAGGAGCGTTTTCTCCAGGTGCAGTCCATGATGTACGATCTGATGGA GTGGAGGTCCCAGCTTCTCTCAGGAACCTTACCCAAGGATGAGCTGAAGGAACTGAAGCA GAAAGTCACGTNCAAAATTGACTATGGNCACAAAATCCTTGAGCTTGATTTGATTGTCAG AGATGAAGACGGNAATATCTTGGACCCCTGATATACCAGTGTCATCAGCTTGGTCCATGC ACATGAGGAANGCACTGATAAAATCACAGAGCGTATCAAAGAGAAATGTCNAAAGACAGC CAGATTATGCATGTATCCCGGATCTCTCATA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004946 |
| Insert Size | 6000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004946.1, NP_004937.1 |
| RefSeq Size | 6050 bp |
| RefSeq ORF | 5493 bp |
| Locus ID | 1794 |
| UniProt ID | Q92608 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Fc gamma R-mediated phagocytosis |
| Gene Summary | The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211198 | DOCK2 (Myc-DDK-tagged)-Human dedicator of cytokinesis 2 (DOCK2) |
CNY 13,780.00 |
|
| RC211198L1 | Lenti ORF clone of Human dedicator of cytokinesis 2 (DOCK2), Myc-DDK-tagged |
CNY 15,680.00 |
|
| RG211198 | DOCK2 (tGFP-tagged) - Human dedicator of cytokinesis 2 (DOCK2) |
CNY 13,904.00 |
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