Pml (NM_178087) Mouse Tagged ORF Clone
CAT#: MR226141
- TrueORF®
Pml (Myc-DDK-tagged) - Mouse promyelocytic leukemia (Pml), transcript variant 2
ORF Plasmid: tGFP
"NM_178087" in other vectors (4)
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CNY 8,840.00
CNY 300.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | 1200009E24Rik; AI661194; Trim19 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MR226141 representing NM_178087
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAAACTGAACCAGTTTCCGTGCAGAAGGTACCTGCACCCCCTGGATCTCCCTGTCGACAACAGGACT CTGCCCTGACCCCCACGCCCACCATGCCTCCCCCAGAGGAACCCTCCGAAGACTATGAACACAGCCAAAG CCCTGCAGAGCAAGCCATACAGGAGGAATTTCAGTTTCTGCGCTGCCCGAGCTGCCAGGCCCAAGCCAAG TGCCCCAAACTGCTGCCTTGCCTGCACACGCTGTGCTCCGGATGCCTGGAGGCGCCTGGCCTGCAGTGCC CCATCTGCAAGGCTCCTGGGCAGGCCGATGCTAATGGGGAGGCCCTGGATAACGTGTTCTTCGAGAGCCT GCAGCGGCGCCTGGCGGTGTTCCGGCAGATCGTGGATGCTCAGGCTGCGTGCACCCGCTGCAAAGGCTTG GCCGACTTCTGGTGTTTCGAGTGTGAACAGCTCATTTGCAGCAAGTGCTTCGAAGCACACCAGTGGTACC TCAAGCATGAGGCCCGGCCCCTGGCTGATCTCCGCGACAATTCAGTGAGCAGCTTCCTCGACAGTACGCG CAAGTCCAATATCTTCTGCTCCAATACCAACCACCGCAACCCTGCGCTGACTGACATCTACTGCCGAGGC TGCGCCAAGCCTCTGTGTTGCACATGCGCGCTCCTGGACCGCAACCACAGCCATCTCCATTGCGATATTG GTGAGGAGATTCAGCAGTGGCATGAGGAACTAGGCACCATGACACAGACTCTGGAGGAGCAGGGCAGAAC CTTCGACAGTGCCCATGCACAGATGTGCTCAGCTATAGGACAGCTGGACCACGCACGCGCAGACATTGAG AAGCAGATCCGCGCACGCGTGCGCCAGGTGGTAGACTACGTGCAGGCTCAGGAGCGCGAGCTGCTCGAGG CGGTGAATGACCGCTACCAGCGCGACTACCAGGAAATAGCTGGCCAGCTGAGCTGCCTGGAAGCTGTGCT GCAGCGCATCCGCACTAGTGGGGCGCTGGTCAAGAGGATGAAGCTCTATGCCTCCGACCAGGAGGTGCTG GATATGCACAGCTTTCTGCGCAAGGCACTCTGTAGCTTGCGCCAGGAGGAGCCCCAGAACCAGAAAGTCC AGCTGCTCACCAGAGGTTTCGAGGAGTTCAAGCTGTGCCTGCAGGACTTCATCTCCTGCATCACCCAGAG GATAAATGCAGCTGTAGCCAGCCCAGAGGCAGCCAGCAATCAACCAGAGGCAGCCAGCACTCACCCAGTG ACAACCAGCACGCCTGAGGACCTTGAGCAGCCCAAAGAAGTGCAGAGTGTACAGGCTCAGGCCCTAGAGC TGTCTAAGACCCAACCTGTGGCTATGGTAAAAACAGTGCCTGGAGCACACCCTGTACCAGTGTATGCCTT TTCAATGCAAGGCCCCACCTACAGAGAGGAGGCTTCTCAGACAGTCGGCTCCATGAAGAGGAAGTGCTCC CACGAAGATTGCTCCAGGAAGATCATCAAGATGGAGTCCACAGAGGAGAACGAGGACAGGTTGGCCACAA GCTCCCCCGAGCAGTCCTGGCCCAGCACTTTCAAGGCCACCTCCCCTCCCCATCTGGATGGGACTTCCAA CCCTGAGAGCACCGTCCCTGAAAAAAAGATCCTCCTGCCCAACAACAATCATGTTACCAGTGACACAGGG GAAACAGAGGAGCGAGTTGTGGTGATCAGCAGCTCAGAGGATTCGGACACCGAGAATCTGTCCTCCCACG AGTTGGACGATAGCAGCAGTGAGTCCAGCAGCCTGCAGCTGGAGGGCCCCAATTCCCTCAAGGCCTTGGA TGAGAGCCTCGCCGAACCCCACTTAGAAGACAGGACCCTGGTTTTCTTTGACCTCAAGATTGACAATGAA ACCCAGAAAATTAGCCAGCTGGCCGCGGTGAACCGGGAAAGCAAGTTCCGTGTGCTCATCCAGCCCGAGG CCTTCAGTGTCTACTCCAAAGCTGTCTCCCTGGAGGCGGGGCTCCGGCACTTCCTCAGCTTCCTCACCAC CATGCACCGTCCCATCTTGGCGTGTTCTAGGCTGTGGGGGCCGGGACTCCCCATCTTCTTCCAGACCCTG AGTGATATTAACAAGCTGTGGGAATTCCAGGACACCATCTCAGGTTTCTTGGCCGTGCTGCCCCTCATCC GGGAACGCATACCCGGCGCTAGCAGCTTCAAACTTGGGAACCTAGCCAAGACCTACCTGGCGAGAAACAT GAGCGAACGCAGCGCTCTGGCTTCTGTGCTGGCCATGAGGGACTTGTGCTGCCTCCTTGAGATCTCCCCA GGACTGCCGCTGGCCCAGCATATCTACTCCTTTAGTAGCTTGCAGTGTTTTGCTTCCCTGCAGCCCCTAA TTCAGGCCAGCGTCCTGCCACAGTCCGAGGCCCGCCTCTTGGCCCTCCACAATGTGAGCTTTGTAGAGTT ACTGAATGCATATCGCACCAACAGGCAAGAAGGCTTGAAGAAGTATGTCCACTATCTGAGCCTGCAGACC ACCCCGTTGTCATCGTCGGCTTCCACCCAAGTTGCCCAATTCCTGCAGGCTCTTAGCACCCACATGGAAG GACTGTTGGAAGGCCATGCCCCTGCTGGGGCAGAAGGCAAAGCTGAAAGTAAGGGATGCCTGGCC AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGATAAGGTTTAA >MR226141 representing NM_178087
Red=Cloning site Green=Tags(s) METEPVSVQKVPAPPGSPCRQQDSALTPTPTMPPPEEPSEDYEHSQSPAEQAIQEEFQFLRCPSCQAQAK CPKLLPCLHTLCSGCLEAPGLQCPICKAPGQADANGEALDNVFFESLQRRLAVFRQIVDAQAACTRCKGL ADFWCFECEQLICSKCFEAHQWYLKHEARPLADLRDNSVSSFLDSTRKSNIFCSNTNHRNPALTDIYCRG CAKPLCCTCALLDRNHSHLHCDIGEEIQQWHEELGTMTQTLEEQGRTFDSAHAQMCSAIGQLDHARADIE KQIRARVRQVVDYVQAQERELLEAVNDRYQRDYQEIAGQLSCLEAVLQRIRTSGALVKRMKLYASDQEVL DMHSFLRKALCSLRQEEPQNQKVQLLTRGFEEFKLCLQDFISCITQRINAAVASPEAASNQPEAASTHPV TTSTPEDLEQPKEVQSVQAQALELSKTQPVAMVKTVPGAHPVPVYAFSMQGPTYREEASQTVGSMKRKCS HEDCSRKIIKMESTEENEDRLATSSPEQSWPSTFKATSPPHLDGTSNPESTVPEKKILLPNNNHVTSDTG ETEERVVVISSSEDSDTENLSSHELDDSSSESSSLQLEGPNSLKALDESLAEPHLEDRTLVFFDLKIDNE TQKISQLAAVNRESKFRVLIQPEAFSVYSKAVSLEAGLRHFLSFLTTMHRPILACSRLWGPGLPIFFQTL SDINKLWEFQDTISGFLAVLPLIRERIPGASSFKLGNLAKTYLARNMSERSALASVLAMRDLCCLLEISP GLPLAQHIYSFSSLQCFASLQPLIQASVLPQSEARLLALHNVSFVELLNAYRTNRQEGLKKYVHYLSLQT TPLSSSASTQVAQFLQALSTHMEGLLEGHAPAGAEGKAESKGCLA SGPTRTRRLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-RsrII Cloning Scheme for this gene Plasmid Map |
ACCN | NM_178087 |
ORF Size | 2655 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_178087.4, NP_835188.2 |
RefSeq Size | 5378 bp |
RefSeq ORF | 2658 bp |
Locus ID | 18854 |
UniProt ID | Q60953 |
MW | 98.7 kDa |
Gene Summary | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC222372 | Pml (untagged) - Mouse promyelocytic leukemia (Pml), transcript variant 2, (10ug) |
CNY 11,310.00 |
|
MG226141 | Pml (tGFP-tagged) - Mouse promyelocytic leukemia (Pml) transcript variant 2, (10ug) |
CNY 8,728.00 |
|
MR226141L3 | Lenti ORF clone of Pml (Myc-DDK-tagged) - Mouse promyelocytic leukemia (Pml), transcript variant 2 |
CNY 10,740.00 |
|
MR226141L4 | Lenti ORF clone of Pml (mGFP-tagged) - Mouse promyelocytic leukemia (Pml), transcript variant 2 |
CNY 10,740.00 |