Fbxw11 (NM_001271349) Mouse Untagged Clone

CAT#: MC228095

Fbxw11 (untagged) - Mouse F-box and WD-40 domain protein 11 (Fbxw11), transcript variant 4



  "NM_001271349" in other vectors (1)

CNY 4,940.00


货期*
4周

规格
    • 10 ug

Product images

经常一起买 (3)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms 2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbxw1b; HOS
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC228095 representing NM_001271349
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGAGCCCGACTCGGTGATTGAAGACAAGACCATCGAGCTCATGATCAGTAATGGAACGTCATCTGTGA
TTGTCTCCAGAAAGAGGCCGTCAGAGGGGAACTACCAGAAAGAAAAGGACTTGTGCATTAAGTACTTTGA
CCAGTGGTCTGAATCAGATCAGGTGGAATTTGTGGAGCATCTTATCTCACGGATGTGTCATTATCAGCAT
GGACATATTAACTCTTACCTGAAGCCCATGTTGCAGCGGGACTTTATCACTGCTTTACCAGAGCAAGGCT
TAGATCACATAGCAGAAAACATTCTCTCCTACCTGGATGCCAGGTCTCTGTGTGCAGCAGAGCTGGTGTG
TAAAGAATGGCAGCGAGTGATCTCAGAAGGGATGCTTTGGAAGAAGCTGATTGAGAGGATGGTGCGCACC
GACCCTCTCTGGAAGGGACTCTCAGAAAGAAGAGGCTGGGATCAGTACCTGTTTAAAAACAGACCTACAG
ATGGCCCTCCCAACTCATTTTATAGATCATTATACCCAAAGATTATCCAGGACATAGAGACCATAGAATC
CAACTGGCGGTGTGGACGACACAACTTGCAGAGGATCCAGTGCCGCTCTGAAAATAGTAAGGGTGTCTAC
TGTTTGCAATATGATGATGACAAAATTATCAGTGGCCTCCGGGACAACTCTATCAAGATCTGGGATAAAA
GCAGCTTGGAATGTTTGAAAGTGCTAACGGGCCACACAGGCTCTGTCCTCTGCCTCCAGTATGATGAGCG
AGTCATTGTAACTGGTTCTTCAGACTCCACGGTGAGAGTCTGGGATGTGAACACTGGTGAGGTGCTCAAC
ACACTCATCCACCACAATGAAGCCGTACTGCACTTACGCTTCAGCAATGGACTGATGGTGACTTGTTCCA
AGGACCGTTCCATTGCCGTGTGGGACATGGCTTCTGCCACCGATATCACTTTACGCCGTGTTCTGGTTGG
CCACCGTGCTGCTGTCAATGTAGTAGACTTTGATGATAAATACATCGTGTCTGCTTCAGGAGACAGGACC
ATTAAAGTGTGGAGCACGAGCACATGTGAGTTTGTCCGCACTCTGAATGGGCACAAGCGAGGCATCGCCT
GTCTGCAGTACCGCGACCGGCTTGTTGTTAGTGGATCATCAGATAATACCATCCGGTTATGGGATATTGA
ATGTGGTGCCTGTTTAAGAGTCCTAGAGGGGCACGAAGAATTGGTCCGGTGCATCCGTTTTGATAACAAG
AGGATTGTCAGTGGCGCCTATGATGGGAAGATTAAAGTCTGGGACTTGCAGGCTGCTCTTGACCCTCGGG
CCCCAGCAAGCACATTGTGTCTGCGCACCTTGGTGGAACACTCTGGACGTGTGTTTCGGCTGCAGTTTGA
TGAGTTTCAGATCATCAGCAGCTCCCATGATGACACTATTTTGATTTGGGATTTCTTAAATGTGCCTCCC
AGTGCCCAGAATGAGACCCGCTCTCCCTCCAGAACCTACACCTATATCTCCAGATAG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_001271349
Insert Size 1527 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_001271349.1, NP_001258278.1
RefSeq Size 4174 bp
RefSeq ORF 1527 bp
Locus ID 103583
UniProt ID Q5SRY7
Gene Summary Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity).[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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