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Palb2 (NM_001081238) Mouse Untagged Clone
CAT＃: MC223601
Palb2 (untagged) - Mouse partner and localizer of BRCA2 (Palb2), (10ug)
CNY 14,160.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | BC066140 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC223601 representing NM_001081238
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAAGAGCTTTCCGGGAAGCCCCTCAGCTATGCGGAGAAGGAAAAGTTGAAGGAAAAGCTAGCATTTT TGAAAAAGGAATACAGCAGGACACTTGCTCGACTTCAGCGTGCCAAAAGAGCTGAGAAGGCTAAGAACTC TAAGAAAGCCATAGAAGATGGTGTGCCCCAGCCAGAAGCTTCCTCACAGCTAAGCCACTCTGAATCTATA AATAAAGGCTTTCCTTGTGACACATTGCAAAGCAACCATCTGGATGAGGAGACTGGAGAAAACATCTCTC AGATACTTGATGTTGAACCTCAATCCTTTAACTGTAAACAAGGCAAAGAAGTATTACATACACCAAGAGC AGGTGACATTCAAGGACAACTTTTGCATAGCACCAGCAGCCCTGATGGCAAGAAAGAGCAGAACACGCTT CCGGGGACAACAAAGACGCCGTGGGAGAAGTCATCTGTTTCACAGGAGAAGGAAGATTATTTTGACACTA ATTCTCTGGCGCTCCTTGGTAAGCATCGAAAAGGGCAAGAATCAATCAGTAGGAAGAATTCTAGGACTCC CGTGAGTGAAAAGACTCACCTTTTAAGTCTCAGGTCTCAGATCCCTGACCCTCCAGCACTTGTTACAGGA ATTGGAGAGGGTATATTAATTCCGCCATCTGGCAAATCAGAAAGGGGAATTGATACACTTGTGAGAGGAA ATACTGTCTCCGCGGAGGCTGCAGTTCCTTCATGTACTGCGTCAAACAGCAATCACAGTCAGCACCTTGA GCATACACCTCCTAAAAGTGGCTGCAAAATTACTACTCAGGGCCCGGCTTCATCCACAAACCTGGTGGCA CAAGACCAAAAAATGACTATATTTACAGTAAACTCAGTAGTATATAAAGCTGTGCGTGCCCATGGTCAGC TGCCAGGAAGTCCCAATTCTTGTTCTGTAAATGATCTCACGCATAGTAACTTGCCAGCAAATAGTACCCC AAACTCTAAATCTTTAAAATCTCCCAGTAACACTGTTGATGAGAGAAATGAACCTCTTCAGGAAGATGAA ATTCTTGGTCCATCTAAGAACTTCAACCTGGCAGCAGTCTCTCCTCCTTCCACAGAAAGTCAAATACATT CTTGTACTATGCTTGAAGGCCTTCTGTTTCCTGCAGAATACTATGTTAGAACAACCCGTCGTATGTCAGA TTGTCAGAGAAAAATAGCTCTGGAAGCTGTAATTCAAAGTCATTTGGGTGTCAAAAAGAAAGAGCTTAAA AAGAAAACCAAAGCTACTAAGGCGGTCGTCCTCTCCAGTGAAGACACTGACCAGAGTGAAAGTGGCATGC TGGACACGAGCACGGGACAGTCCAGTTCAGGAAGCCTCTCTCAGAAACTGCTCTCACCAGCTGAGGTCAG CTCTCCTCCAGGACCTGCTGGAAAGGCCACCACACCGCCACCTGGTAGAGGACACAGAGGGAAACGAAAA TCAGCCCGCACCTCCACACTGGGTCACTGCCAGCTGCTTTTTCCTCCTTGTGCCGCACTGGCTGTTAACA GGTCCAAGGGCAAATTCACCAAGCATAAATGTCAGAACAGAGGCGTGGTTATTCATGACTTTGAGTTACC TGATGAAGACTTTGGGCTTCTTAAACTTGAAAAATTGAAGTCCTGCTCGGAAAAACTGATTGAGTCTCCT GACTCAAAAAACTGTGGTGAGAGGCTTCCTAGAGAAGGAAACCATGCTGCTCTGGAGGAACTGCAAAGAG ATTCGGAGACGGAGGGCTTGGAAGAGGAGCTCACTGTTCCACCAGGAGAAGCGTACCGTCCAGGGCCAAC CCTGAGAAGGCAGCCAGGGAGCAAGGACCTTTCTTCATCCATAGTGCTTTTCACTCCTGCAGACACTGCT GCGCCTAACGACAGTGGCAGGCCTCCTCCCTCCCTGTGCTCACCTGCTTTCCCCATCTTAGGCATGACTC CAGCTCTTGGCTCCCAAGCAGCCGGTGAGACTCTATCTACTGAAGCTGCACAGCCTTGCTCTACATCCCA ACCTCCTCTCTTGGGAGACACAAACAGTCTTGTCAATAACAGTAAACAGTGCAACAGTTCAGCCTGCTCA CCAAAACCGGACACCAACCTGCAAGCGTCAGGTAGGCAAGGACAACCTGCCTGTGACAGTGACTCTGGCC CCCAAGCAACACCTCTACCTGTTGAGTCATTCACTTTCAGAGAAAATCAGCTTTGTGGAAATGCATGCCT CGAGTTACATGAACATTCCACTGAACAGACTGAAACTGCAGATCGCCCTGCTTGTGACAATCTAAACCCA GGAAACCTACAGTTGGTTTCAGAGTTAAAGAATCCTTCCAGTTCCTGCTCTGTGGATGTGAGCGCCATGT GGTGGGAAAGAGCTGGTGCTAAGGAGCCATGTATCGTAACTGCTTGTGAAGATGTAGTTTCTCTTTGGAA ACCCTTGAATTCTCTGCAGTGGGAGAAAGTTCATACCTGGCACTTCACAGAGGTTCCAGTATTACAAATA GTTCCAGTGCCTGATGTTTACAATCTTATATGTGTAGCTTTGGGAAGTTTGGAAATCAGAGAAATCAGGG CGTTGCTGTGCTCTTCTGGTGATGACAGTGAAAAGCAAGTCCTCCTGAAATCTGGAGATATAAAAGCTAT GCTTGGCCTGACAAAGCGGAGGCTAGTTAGTAGCACTGGGACCTTTTGCAATCAACAAATACAAATCATG ACATTTGCTGACGACGGAAGCAGCAAAGATGAACAGCTTTTGATGCCTCCTGATGAGACTGTACTGACTT TTGCTGAAGTCCAAGGGACGCAGGAAGCTCTGCTTGGTACTACCACTGTGAACAGCATTGTGATCTGGAA TTTAAAAACCGGCCAGCTCCTGAAGAAGATGCACATTGATGACTCCTACCAGGCTTCGGTCTGTCACGGA GCCTATTCTGAGAAGGGGCTCCTGTTTGTTGTTGTGAGTCAACCTTGTGCCAAAGAGAGCCAGGCCCTTG GAAGCCCTGTGTTCCAGCTGCTGGTGATTAACCCTAAGACGGCCCAGAGTGTGGGTGTTCTGCTGTGTTC CCTTCCTCAGGGGCAGGCTGGAAGGTTCCTGGAAGGGGATGTGAAAGATCATGTCGCAGCAGCAGTCCTG ACTTCTGGGACAATTGCCATTTGGGATTTGCTTCTGGGTCACTGCACGGCTCTCCTCCCACCTGTCTCTG ACCAGAGTTGGTCTTTGGTTAAATGGTCGGGTACAGATTCTCACTTGCTAGCTGGACAAAAGGATGGAAA TATATTTATATACCGATACTTTTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001081238 |
| Insert Size | 3315 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001081238.2, NP_001074707.1 |
| RefSeq Size | 3750 bp |
| RefSeq ORF | 3315 bp |
| Locus ID | 233826 |
| UniProt ID | Q3U0P1 |
| Gene Summary | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG223631 | Palb2 (tGFP-tagged) - Mouse partner and localizer of BRCA2 (Palb2), (10ug) |
CNY 12,160.00 |
|
| MR223631 | Palb2 (Myc-DDK-tagged) - Mouse partner and localizer of BRCA2 (Palb2) |
CNY 11,020.00 |
|
| MR223631L3 | Lenti ORF clone of Palb2 (Myc-DDK-tagged) - Mouse partner and localizer of BRCA2 (Palb2) |
CNY 12,920.00 |
|
| MR223631L4 | Lenti ORF clone of Palb2 (mGFP-tagged) - Mouse partner and localizer of BRCA2 (Palb2) |
CNY 12,920.00 |
