C9orf72 (NM_018325) Human 3' UTR Clone
CAT#: SC216017
3' UTR clone of chromosome 9 open reading frame 72 (C9orf72) transcript variant 1 for miRNA target validation
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CNY 5,795.00
货期*
3周
规格
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经常一起买 (2)
Specifications
Product Data | |
Product Name | C9orf72 (NM_018325) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1 |
ACCN | NM_018325 |
Insert Size | 1720 bp |
Sequence Data |
>SC216017 3’UTR clone of NM_018325
The sequence shown below is from the reference sequence of NM_018325. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAAGAACGAGATGTTCTAATGACTTTTTAAATGTGTAACTTAATAAGCCTATTCCATCACAATCATGAT CGCTGGTAAAGTAGCTCAGTGGTGTGGGGAAACGTTCCCCTGGATCATACTCCAGAATTCTGCTCTCAG CAATTGCAGTTAAGTAAGTTACACTACAGTTCTCACAAGAGCCTGTGAGGGGATGTCAGGTGCATCATT ACATTGGGTGTCTCTTTTCCTAGATTTATGCTTTTGGGATACAGACCTATGTTTACAATATAATAAATA TTATTGCTATCTTTTAAAGATATAATAATAGGATGTAAACTTGACCACAACTACTGTTTTTTTGAAATA CATGATTCATGGTTTACATGTGTCAAGGTGAAATCTGAGTTGGCTTTTACAGATAGTTGACTTTCTATC TTTTGGCATTCTTTGGTGTGTAGAATTACTGTAATACTTCTGCAATCAACTGAAAACTAGAGCCTTTAA ATGATTTCAATTCCACAGAAAGAAAGTGAGCTTGAACATAGGATGAGCTTTAGAAAGAAAATTGATCAA GCAGATGTTTAATTGGAATTGATTATTAGATCCTACTTTGTGGATTTAGTCCCTGGGATTCAGTCTGTA GAAATGTCTAATAGTTCTCTATAGTCCTTGTTCCTGGTGAACCACAGTTAGGGTGTTTTGTTTATTTTA TTGTTCTTGCTATTGTTGATATTCTATGTAGTTGAGCTCTGTAAAAGGAAATTGTATTTTATGTTTTAG TAATTGTTGCCAACTTTTTAAATTAATTTTCATTATTTTTGAGCCAAATTGAAATGTGCACCTCCTGTG CCTTTTTTCTCCTTAGAAAATCTAATTACTTGGAACAAGTTCAGATTTCACTGGTCAGTCATTTTCATC TTGTTTTCTTCTTGCTAAGTCTTACCATGTACCTGCTTTGGCAATCATTGCAACTCTGAGATTATAAAA TGCCTTAGAGAATATACTAACTAATAAGATCTTTTTTTCAGAAACAGAAAATAGTTCCTTGAGTACTTC CTTCTTGCATTTCTGCCTATGTTTTTGAAGTTGTTGCTGTTTGCCTGCAATAGGCTATAAGGAATAGCA GGAGAAATTTTACTGAAGTGCTGTTTTCCTAGGTGCTACTTTGGCAGAGCTAAGTTATCTTTTGTTTTC TTAATGCGTTTGGACCATTTTGCTGGCTATAAAATAACTGATTAATATAATTCTAACACAATGTTGACA TTGTAGTTACACAAACACAAATAAATATTTTATTTAAAATTCTGGAAGTAATATAAAAGGGAAAATATA TTTATAAGAAAGGGATAAAGGTAATAGAGCCCTTCTGCCCCCCACCCACCAAATTTACACAACAAAATG ACATGTTCGAATGTGAAAGGTCATAATAGCTTTCCCATCATGAATCAGAAAGATGTGGACAGCTTGATG TTTTAGACAACCACTGAACTAGATGACTGTTGTACTGTAGCTCAGTCATTTAAAAAATATATAAATACT ACCTTGTAGTGTCCCATACTGTGTTTTTTACATGGTAGATTCTTATTTAAGTGCTAACTGGTTATTTTC TTTGGCTGGTTTATTGTACTGTTATACAGAATGTAAGTTGTACAGTGAAATAAGTTATTAAAGCATGTG TAAACATTGTTATATATCTTTTCTCCTAAATGGAGAATTTTGAATAAAATATATTTGAAATTTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_018325.5 |
Synonyms | ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1 |
Summary | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] |
Locus ID | 203228 |
MW | 67.7 |
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