SMURF 2 (SMURF2) (NM_022739) Human 3' UTR Clone

Specifications

Product Data
Product Name	SMURF 2 (SMURF2) (NM_022739) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_022739
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC213364 3’UTR clone of NM_022739 The sequence shown below is from the reference sequence of NM_022739. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAAGAAACATGTGGATTTGCTGTGGAATGACAAGCTTCAAGGATTTACCCAGGACTCTATTTATACAAC CCTGACTGACAGCCTCCTTTCAGCAGAGTTTCAAAGAATATGCTGAAATACAGGAAAACACTCCCCCCC CCCCCCTTTTTTTTTTTTTTTTTACATTTTAGGACACTGTGAGGGGAAAGGACAATTTTGAAATTCCTT TTCAAGGAAAAAAAAGGTCTTTATGCTTTGCCATGAGGCCACATTCAGCTGCTATTTAAACTTAATATC TTGAACCTAAAGAATGCTGACTTTTCCTACATTTCCAGAGTTAGGCAGTATTCTACACTTAAAGACTAC TACTATTTTTATAAAAGGTAATCTATTCAAATTTCTTCACAGATTTCAAGTCTCTCAAACATCAAGACA ACTTCAGCAGTCGGTACAAGTCACATTTCATTTTGATTGAATACATGATCTTGAACAGCTCCTGTACTT GCTCTTTGTAAAAAAAAATAAAATTATTTTGAATTATTCTACCTTTGTAAACAATTGGCTAAAAGAATC ATCTTTAAGAAATTAAGCCATTTACATGTTTGTGTTTTTCTATAGCAGAGCATTATATTTTGCATTATA TGTTTCAACCTAGTCTAAGTGGGTCTTTTTTACATTTTTCAAGAACGGATTTCCTGGAATACAGCGATA TAATTTTGGTTGTCAAATTCCTAATGCAACCATTTAGTCTAAACTTAGTCATTTATTTGTGACAATAAG ATGTGTTCAGGGGCTCCCTGTTTTTAAGAGACTCTTTTAAAAAAAAAAAAACCTAATGTTTTTATCTTG AGTCAATATGATTAGGTATTTTGGATTTACTTTTAATCTTAAAATACTGCATTTTTATAGCTTCTCAGA GCATGTGGATGGGATGGGATTTTCGTTATTTTGCTGGGTCAGCTTATCTTTAATATATGGACTATTCCT ATAAACCAAAGTCTCTGACAAGTGCACCTAATTTATATTGTATTTTAACTACAGTGTAAGTTTCCATTA ACAAAACCATCCTAAAGCGTTAACTGCTCATAATTTTAATCAGCTACAGTTATGAAAAAGGAAGAATTT TGCTCTAAAGATTATTAATAAGCTTAGAAAATCCTGCTTTTACCTAACAGAATGAAGTGGGGTTGAGGG GCGGTAGTATGAACAGTGATTCTAACTCTATGGCGTAAATTACTTTGAAGAGTTCATTTTGGAAGTAAG GGAATCCCGCTTCCCTTGGTGTTGAAGATCTGCATCTGATTTTGAAACGTCCAGATTTAGCTTTCAAGG TGCGTGCATGTTGAATGATCCAGAAGCAACGAAAACTCTGGGGTGAGGGATTGAAAAAATCTGAAATCA CAGTTGGATTTTTAAATTCAACCATCAAAAATATGTACTATCAGTTTTTTTTTACATTGATGTGAAATA AGCAAATTTTCATGATAATTAAGCTGCAAAATTTAAAGTTATCAAGTAAATAGGTCCTCTGTGTTCTGT TTCATGTGATGGAGTGGGTTTCAGTCTGTGTTCTTGGAGCCAAAGGGTTCCTCAGGGGTGCCTCAGGAG TAATGGTTTAAGAGAAGAGGGGCAATGAGAGGGAGCGAGGGGGAAGGCCTAGTTGGTATTTGAGCAGGG GCCTTAGGCTCCATATCCCCACCCCCTTTACCCAGAACAGCCCATTTTTCTTATGTATATTGGAATTTC AAGTAAGCTTTCATGGGGTGCAGTGGGGCGGGGAGGAATGGATGGGATAAAAAAAGTGGAGATTTTGCT GCTTTAAAAAAGTTGAGAACTACTTGTGTAGTTTTTAAGTATTTTAATGTATTTCATTTGGCCAAATTC AACTGCCACAAGCAAGCTAGTCATAGTTGTAACTGTGCAGTGGTAATATGCTTATGCCTACCTTTTTCC TCTCAAACAATTTGTTTTTTTTACATTGCATTCTGAGTACTGAAGAGCATCTTGAAATGTATGGAAGT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022739.4
Summary	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.[UniProtKB/Swiss-Prot Function]
Locus ID	64750
MW	76.5

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