TAB1 (NM_153497) Human 3' UTR Clone

Specifications

Product Data
Product Name	TAB1 (NM_153497) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	3'-Tab1; MAP3K7IP1
ACCN	NM_153497
Insert Size	591 bp
Sequence Data	Insert Sequence (showhide) >SC207454 3’UTR clone of NM_153497 The sequence shown below is from the reference sequence of NM_153497. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACCTCCTGGGCAGCCTGACCCCAGGGTAGGAAGGAAGCGCCTACACCAAGGGGCCCTCTGGGAGCTGA GATCATCCTGGGGTTTTGTCGCCTGGTCTGACTTGTGCACTGGGATCTTCTCGTGCCAGGCCAGGCCCC GCCCCCTCCCCGGGACTGGGCAGACCCCCTCCCTCATGCATCTGTGTCCACTGAGGCTTCCCTCACCTA GAATGGCCCATCCTTCAGGACCCAGCTCACTCTCATCTTCTTTCCAGGGACTTATCCCCCAAGGCTGTC CTCTGTTCTGGTGAGCTCAGGGCTCTTGGAACTTGGTCTGCAGTGACTCTGGGGTTCCTGGTTAGGACC CATGTTCTCTAGGTCCCAGCACCCTGCACGGGGCAGTGTTTGTGACACTGGGCCCAGCTATTCTGAGAG AAGGACTCCAACCTTCCATCAGGTGTGGCCCGAGATGTGGGTGGCCCTGGGCATGGGGCATGGATGCAT TGTGACTTTCATGGGCCTCTTCTGCAAAAAAAAAATTAAAATTATACTTTATGACTATTGGTAGAAAGA TAAATATATTAATACATTAAAATTTCTCTTTGAGTAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_153497.3
Synonyms	3'-Tab1; MAP3K7IP1
Summary	The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Locus ID	10454
MW	21

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