Stefin B (CSTB) (NM_000100) Human 3' UTR Clone

Specifications

Product Data
Product Name	Stefin B (CSTB) (NM_000100) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
ACCN	NM_000100
Insert Size	282 bp
Sequence Data	Insert Sequence (showhide) >SC203375 3’UTR clone of NM_000100 The sequence shown below is from the reference sequence of NM_000100. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCCAAGCATGATGAGCTGACCTATTTCTGATCCTGACTTTGGACAAGGCCCTTCAGCCAGAAGACTGAC AAAGTCATCCTCCGTCTACCAGAGCGTGCACTTGTGATCCTAAAATAAGCTTCATCTCCGGGCTGTGCC CCTTGGGGTGGAAGGGGCAGGATTCTGCAGCTGCTTTTGCATTTCTCTTCCTAAATTTCATTGTGTTGA TTTCTTTCCTTCCCAATAGGTGATCTTAATTACTTTCAGAATATTTTCAAAATAGATATATTTTTAAAA TCCTTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000100.4
Synonyms	CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
Locus ID	1476
MW	10.8

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