ADCK3 (COQ8A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 293-353 of Human ADCK3.
Specificity	ADCK3 (N323) polyclonal antibody detects endogenous levels of ADCK3 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 72 kDa
Gene Name	aarF domain containing kinase 3
Database Link	Entrez Gene 56997 Human UniProt ID Q8NI60
Background	CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the protein kinase superfamily. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may be implicated in ubiquinone deficiency, which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events.
Synonyms	aarF domain-containing protein kinase 3; ADCK3; Atypical kinase COQ8A, mitochondrial; CABC1; Chaperone-ABC1-like; Chaperone activity of bc1 complex-like; Coenzyme Q protein 8A; COQ8A; PP265
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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