UBE2E2 Rabbit Polyclonal Antibody
CAT#: TA369783
UBE2E2 rabbit polyclonal antibody
Size: 25 ul
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CNY 1,999.00
CNY 3,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm and Nucleus |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length fusion protein |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Gene Name | ubiquitin conjugating enzyme E2 E2 |
Database Link | |
Background | Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). The first step in the ubiquitination process requires the ATP-dependent activation of the ubiquitin C-terminus and the assembly of multi-ubiquitin chains by the E1 enzyme. The ubiquitin chain is then conjugated to the E2 enzyme to generate an intermediate ubiquitin-E2 complex. The E3 enzyme then catalyzes the transfer of ubiquitin from E2 to the appropriate protein substrate, thereby targeting that substrate for degradation. A wide range of enzymes facilitate this proteolytic ubiquitin pathway, one of which is UBE2E2 (also known as UBCH8 in human), which functions as an E2 enzyme and catalyzes the ATP-dependent covalent attachment of ubiquitin to target proteins, thereby playing an important role in protein degradation. |
Synonyms | FLJ25157; OTTHUMP00000161048; OTTHUMP00000208342; UBCH8 |
Reference Data |
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