SIRP alpha (SIRPA) Rabbit Monoclonal Antibody [Clone ID: DM8]

Specifications

Product Data
Clone Name	DM8
Applications	ELISA, FC, IF, IP
Recommend Dilution	Flow Cyt 1/100; IP 1/30
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant human SIRPα (Glu31-Arg370)(TP723932) produced by using human HEK293 cells
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Preservative: 0.1% Procline 300
Reconstitution Method	Reconstitute with deionized water
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Predicted Protein Size	55kDa
Gene Name	signal regulatory protein alpha
Database Link	Entrez Gene 140885 Human UniProt ID P78324
Background	The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Synonyms	BIT; CD172A; MFR; MYD-1; MYD1; p84; PTPNS1; SHPS-1; SHPS1; SIRP; SIRP-ALPHA-1; Sirp-alpha-2; Sirp-alpha-3; SIRPalpha; SIRPalpha2
Reference Data

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