PRMT7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:1000-2000, WB: 1:200-1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 526-692 amino acids of human protein arginine methyltransferase 7
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	78 kDa
Gene Name	protein arginine methyltransferase 7
Database Link	NP_001171753 Entrez Gene 214572 MouseEntrez Gene 361402 RatEntrez Gene 54496 Human UniProt ID Q9NVM4
Background	Protein arginine methyltransferase 7?is a?protein?that in humans is encoded by the?PRMT7?gene.?Arginine?methylation?is an apparently irreversible protein modification catalyzed by arginine methyltransferases; such as PMT7; using?S-adenosylmethionine?(AdoMet) as the methyl donor. Arginine methylation is implicated in?signal transduction; RNA transport; and?RNA splicing. May be involved in etoposide-induced cytotoxicity; a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
Synonyms	FLJ10640; KIAA1933
Reference Data
Protein Families	Druggable Genome

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