CENPE Mouse Monoclonal Antibody [Clone ID: 1H12]

Specifications

Product Data
Clone Name	1H12
Applications	IF
Recommend Dilution	ELISA: 1:5,000 - 1:20,000, WB: 1:500 - 1:2,000, IF: 1:500 - 1:2,000, IP: 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This protein A purified monoclonal antibody was produced by repeated immunizations with a full length recombinant protein corresponding to human CENP-E protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	centromere protein E
Database Link	NP_001804 Entrez Gene 1062 Human UniProt ID Q02224
Synonyms	CENP-E; KIF10; MCPH13; PPP1R61
Note	CENP-E, Centrosome-associated protein E, is a kinesin-like minus-end directed microtubule motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometa-phase. CENP-E is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. CENP-E interacts with CENP-F and BUBR1 kinase. CENP-E associates with kinetochores during congression, relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency

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