Nestin (NES) Rabbit Polyclonal Antibody
CAT#: TA319444
Rabbit polyclonal anti-Nestin antibody
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CNY 8,025.00
货期*
5周
规格
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Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | ELISA: 1:20,000 - 1:80,000, WB: 1:500 - 1:3,000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1484-1500 of human Nestin protein. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | nestin |
Database Link | |
Synonyms | Nbla00170 |
Note | Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
Reference Data | |
Protein Families | ES Cell Differentiation/IPS |
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