TBC1D1 Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1 - 4 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | TBC1D1 antibody was raised against a 22 amino acid synthetic peptide from near the carboxy terminus of human TBC1D1. The immunogen is located within the last 50 amino acids of TBC1D1. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | TBC1 domain family member 1 |
Database Link | |
Background | TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity. |
Synonyms | TBC; TBC1 |
Reference Data | |
Protein Families | Druggable Genome |
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