CARD8 Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | CARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8. |
Formulation | PBS containing 0.02% sodium azide. |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
Gene Name | caspase recruitment domain family member 8 |
Database Link | |
Background | Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis (1,2), and caspase-1 and its related proteins ICEBERG and pesudo-ICE (3). Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein (2,4), it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappaB activation. |
Synonyms | CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN |
Reference Data |
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