KRT13 Mouse Monoclonal Antibody [Clone ID: Ks13.1]

Specifications

Product Data
Clone Name	Ks13.1
Applications	IF, IHC, WB
Recommend Dilution	Western Blot. Immunofluorescence. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 1/10. Protease pretreatment improves the performance of this excellent marker in immunohistochemistry with PBS, pH 7.4 Incubation time: 1h at RT, extended with parafin.
Reactivity	Bovine, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Keratin K13 of Mr 54.000 purified from human esophagus.
Specificity	Ks 13.1 represents an excellent marker to discriminate non-cornified squamous epithelia from those of different origin. Polypeptide reacting: Mr 54 000 polypeptide human keratin K13 (formerly designated cytokeratin13; with minor affinity to keratins K14, Mr 50 000, and K16, Mr 48 000). Tumors specifically detected: several squamous cell carcinomas, e.g. cervix carcinoma; transitional cell carcinoma of the bladder; craniopharyngioma.
Formulation	PBS, pH 7.4 State: Purified State: Lyophilized purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.09% Sodium Azide
Reconstitution Method	Restore in 1 ml dist. water.
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	keratin 13
Database Link	Entrez Gene 3860 Human UniProt ID P13646
Background	Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.
Synonyms	CK-13, CK13, Keratin-13, KRT13, K13, KRT-13
Reference Data

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