KDM5D (C-term) Rabbit Polyclonal Antibody

CAT#: AP60001PU-L

KDM5D (C-term) rabbit polyclonal antibody, Purified



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CNY 4,917.00


货期*
5周

规格
    • 200 ug

Cited in 1 publication.

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Specifications

Product Data
Applications WB
Recommend Dilution Western blot: 1-5 μg/ml.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure (> 95%) recombinant Human JARID1D (Leu1248-Leu1539) fused to a C-terminal His-tag (6x His) derived from E. coli (Cat.-No AR60001PU-N)
Specificity This antibody detects Human JARID1D.
Other species not tested.
Formulation State: Purified
State: Lyophilized purified Ig fraction
Reconstitution Method Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name lysine demethylase 5D
Background H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
Synonyms Lysine-specific demethylase 5D, KDM5D, SMCY, HYA, HY, H-Y
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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