KDM5D (C-term) Rabbit Polyclonal Antibody
CAT#: AP60001PU-L
KDM5D (C-term) rabbit polyclonal antibody, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 4,917.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western blot: 1-5 μg/ml. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Highly pure (> 95%) recombinant Human JARID1D (Leu1248-Leu1539) fused to a C-terminal His-tag (6x His) derived from E. coli (Cat.-No AR60001PU-N) |
Specificity | This antibody detects Human JARID1D. Other species not tested. |
Formulation | State: Purified State: Lyophilized purified Ig fraction |
Reconstitution Method | Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/ml. |
Purification | Protein A Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Gene Name | lysine demethylase 5D |
Database Link | |
Background | H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available. |
Synonyms | Lysine-specific demethylase 5D, KDM5D, SMCY, HYA, HY, H-Y |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.
,null,
European journal of medicinal chemistry
,PubMed ID 30802730
[KDM5D]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...