Serpinb9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	Flow Cytometry: The typical starting working dilution is 1/50. Western blot: The typical starting working dilution is 1/50.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant GST-Spi-6
Specificity	The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa. It shows no cross-reactivity with Mouse proteins related to Spi-6.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	serine (or cysteine) peptidase inhibitor, clade B, member 9
Database Link	Entrez Gene 20723 Mouse UniProt ID O08797
Background	Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.
Synonyms	Cytoplasmic antiproteinase 3, serpin B9, PI-9
Reference Data

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